Evidence map›Paper›PMID 26008760›Full record

ReviewArchives of biochemistry and biophysics2015

Transition state theory for enzyme kinetics.

Donald G Truhlar

Abstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. High-throughput physics-based enzyme engineering.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Protein Dynamics and Enzymatic Catalysis.The journal of physical chemistry. B · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. The Second Law of Thermodynamics as a Force Law.Entropy (Basel, Switzerland) · 2018
    Article
  13. Article
  14. Kinetics of low-temperature transitions and a reaction rate theory from non-equilibrium distributions.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Donald G TruhlarDepartment of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455, United States. Electronic address: truhlar@umn.edu.

Funding

A New Paradigm for Biomolecular SimulationsRC1GM091445 · NIGMS · UNIVERSITY OF MINNESOTA · PI GAO, JIALI, TRUHLAR, DONALD G · 2009 to 2010
$904k
NIGMS NIH HHS 1RC1GM091445NIGMS NIH HHS RC1 GM091445
6 · The paper itself

Abstract

This article is an essay that discusses the concepts underlying the application of modern transition state theory to reactions in enzymes. Issues covered include the potential of mean force, the quantization of vibrations, the free energy of activation, and transmission coefficients to account for nonequilibrium effect, recrossing, and tunneling.

Indexed as

Models, BiologicalEnzyme ActivationEnzymesKineticsQuantum TheoryThermodynamicsEnzymesEnzyme kineticsFree energyQuantum effectsTransition state theoryTunneling

Identifiers

PMID26008760
PMCPMC4555010

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.