Evidence map›Paper›PMID 26008737›Full record

ArticleMolecular psychiatry2016

Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.

J Nomura, H Jaaro-Peled, E Lewis, P Nuñez-Abades, F Huppe-Gourgues, T Cash-Padgett, F Emiliani, M A Kondo, A Furuya, M A Landek-Salgado and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Article
  5. Genetic Analysis ofFrontiers in neurology · 2018
    Article
  6. The Gliotransmitter d-Serine Promotes Synapse Maturation and Axonal StabilizationThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

J NomuraDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
H Jaaro-PeledDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
E LewisDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
P Nuñez-AbadesDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
F Huppe-GourguesDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
T Cash-PadgettDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
F EmilianiDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M A KondoDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
A FuruyaMental Biology, RIKEN Brain Science Institute, Wako, Japan.
M A Landek-SalgadoDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Y AyhanDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
A KamiyaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
T TakumiMental Biology, RIKEN Brain Science Institute, Wako, Japan.
R HuganirDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M PletnikovDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
P O'DonnellDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
A SawaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Maryland, Baltimore · USHiroshima University · JPRIKEN Center for Brain Science · JP

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI LEEK, JEFFREY T. · 2011 to 2020
$19.9M
PDZ DOMAINS AND EXCITATORY SYNAPTIC FUNCTIONR01NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1997 to 2020
$8.6M
Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9M
Research Center for Molecular Pathogenesis of SchizophreniaP20MH084018 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GALLAGHER, MICHAELA · 2008 to 2010
$3.3M
Nuclear pathway of DISC1 in major mental illnesses: biochemistry and cell biologyR01MH069853 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2004 to 2012
$3.2M
ELECTROPHYSIOLOGY OF THE PREFRONTAL CORTEXR01MH057683 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI O'DONNELL, PATRICIO · 1997 to 2012
$3.2M
DAAO Inhibitors for the treatment of SchizophreniaR01MH091387 · NIMH · JOHNS HOPKINS UNIVERSITY · PI TSUKAMOTO, TAKASHI · 2011 to 2014
$2.1M
Oxidative stress and schizophrenia: combination of cell biology and brain imagingR01MH092443 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2015
$1.8M
Defining of Neurodevelopmental Pathways Regulated by Neuregulin- DISC1 InteractioRC1MH088753 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, SAWA, AKIRA · 2009 to 2010
$933k
PICK1 knockout mice: role for D-serine in neonatal forebrainsR21MH085226 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2010 to 2011
$369k
Electrophysiology of the Prefrontal CortexR56MH057683 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI O'DONNELL, PATRICIO · 2008 to 2008
$359k
NIMH NIH HHS MH-057683NIMH NIH HHS MH-069853NIMH NIH HHS MH-083728NIMH NIH HHS MH-084018NIMH NIH HHS MH-085226NIMH NIH HHS MH-088753NIMH NIH HHS MH-091387NIMH NIH HHS MH-092443NIMH NIH HHS MH-094268NIMH NIH HHS P20 MH084018NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH057683NIMH NIH HHS R01 MH069853NIMH NIH HHS R01 MH083728NIMH NIH HHS R01 MH091387NIMH NIH HHS R01 MH092443NIMH NIH HHS R21 MH085226NIMH NIH HHS R56 MH057683NIMH NIH HHS RC1 MH088753NINDS NIH HHS R01 NS036715
6 · The paper itself

Abstract

NMDA glutamate receptors have key roles in brain development, function and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and how neonatal deficits in NMDA-receptor-mediated neurotransmission affect adult brain functions and behavior. Likewise, the role of D-serine during development remains elusive. Here we report behavioral and electrophysiological deficits associated with the frontal cortex in Pick1 knockout mice, which show D-serine deficits in a neonatal- and forebrain-specific manner. The pathological manifestations observed in adult Pick1 mice are rescued by transient neonatal supplementation of D-serine, but not by a similar treatment in adulthood. These results indicate a role for D-serine in neurodevelopment and provide novel insights on how we interpret data of psychiatric genetics, indicating the involvement of genes associated with D-serine synthesis and degradation, as well as how we consider animal models with neonatal application of NMDA receptor antagonists.

Indexed as

Mental Disorders2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAction PotentialsAge FactorsAnimalsCarrier ProteinsCell Cycle ProteinsDisease Models, AnimalDopamine AgonistsExcitatory Amino Acid AntagonistsExploratory BehaviorFrontal LobeMaze LearningMiceMice, Inbred C57BLMice, Knockout2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineCarrier ProteinsCell Cycle ProteinsDopamine AgonistsExcitatory Amino Acid AntagonistsNuclear ProteinsPrkcabp protein, mouseSerine

Identifiers

PMID26008737
PMCPMC4661134
OpenAlexW1596152947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.