Evidence map›Paper›PMID 26007680›Full record

Trial reportBMC oral health2015

Effect of nonsurgical periodontal treatment in conjunction with either systemic administration of amoxicillin and metronidazole or additional photodynamic therapy on the concentration of matrix metalloproteinases 8 and 9 in gingival crevicular fluid in patients with aggressive periodontitis.

Anna Skurska, Ewa Dolinska, Małgorzata Pietruska, Jan K Pietruski, Violetta Dymicka, Halina Kemona, Nicole B Arweiler, Robert Milewsk, Anton Sculean

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Anna SkurskaDepartment of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269, Białystok, Poland. annaskurska@wp.pl.
Ewa DolinskaDepartment of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269, Białystok, Poland. ewadolinska@umb.edu.pl.
Małgorzata PietruskaDepartment of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269, Białystok, Poland. mpietruska@wp.pl.
Jan K PietruskiPrivate Practice, ul. Waszyngtona 1/34, 15-269, Białystok, Poland. jpietruski@wp.pl.
Violetta DymickaDepartment of Clinical Laboratory Diagnostics, Medical University of Białystok, ul. Waszyngtona 15, 15-269, Białystok, Poland. piekarskav@yohoo.com.
Halina KemonaDepartment of Clinical Laboratory Diagnostics, Medical University of Białystok, ul. Waszyngtona 15, 15-269, Białystok, Poland. kemona@umb.edu.pl.
Nicole B ArweilerDepartment of Periodontology, Philipps-University of Marburg, Georg-Voigt-Str. 3, D-35039, Marburg, Germany. arweiler@med.uni-marburg.de.
Robert MilewskDepartment of Statistics and Medical Informatics, Medical University of Białystok, ul. Szpitalna 37, 15-295, Białystok, Poland. robert.milewski@umb.edu.pl.
Anton SculeanDepartment of Periodontology, Dental School University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland. anton.sculean@zmk.unibe.ch.
Medical University of Białystok · PLPhilipps University of Marburg · DEUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate in patients with aggressive periodontitis (AgP) the effect of nonsurgical periodontal treatment in conjunction with either additional administration of systemic antibiotics (AB) or application of photodynamic therapy (PDT) on the gingival crevicular fluid (GCF) concentration of matrix metalloproteinases 8 and 9 (MMP-8 and -9).

methodsThirty-six patients with AgP were included in the study. Patients were randomly assigned to treatment with either scaling and root planing (SRP) followed by systemic administration of AB (e.g. Amoxicillin + Metronidazole) or SRP + PDT. The analysis of MMP-8 and -9 GCF concentrations was performed at baseline and at 3 and 6 months after treatment. Nonparametric U-Mann-Whitney test was used for comparison between groups. Changes from baseline to 3 and 6 months were analyzed with the Friedman's ANOVA test with Kendall's index of consistency.

resultsIn the AB group, patients showed a statistically significant (p = 0.01) decrease of MMP-8 GCF level at both 3 and 6 months post treatment. In the PDT group, the change of MMP-8 GCF level was not statistically significant. Both groups showed at 3 and 6 months a decrease in MMP-9 levels. However, this change did not reach statistical significance.

conclusionsWithin the limits of the present study, it may be suggested that in patients with AgP, nonsurgical periodontal therapy in conjunction with adjunctive systemic administration of amoxicilin and metronidazole is more effective in reducing GCF MMP-8 levels compared to the adjunctive use of PDT.

Indexed as

Aggressive PeriodontitisAmoxicillinAnti-Bacterial AgentsAnti-Infective AgentsCombined Modality TherapyDental ScalingFemaleFollow-Up StudiesGingival Crevicular FluidHumansLasers, SemiconductorMaleMatrix Metalloproteinase 8Matrix Metalloproteinase 9MetronidazolePeriodontal DebridementAmoxicillinAnti-Bacterial AgentsAnti-Infective AgentsMatrix Metalloproteinase 8Matrix Metalloproteinase 9MetronidazoleMMP8 protein, humanMMP9 protein, humanPhotosensitizing Agents

Identifiers

PMID26007680
PMCPMC4450832
OpenAlexW1779053237

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.