ReviewNature reviews. Endocrinology2015
Perimenopause as a neurological transition state.
Review in Nature reviews. Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 310 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
310 citing papers in PubMed, 5 syntheses or guidelines pooled it, 553 citations in OpenAlex.
- Transcranial photobiomodulation therapy in older women regarding cognitive functions: a systematic review.Lasers in medical science · 2025Pooled it
- Systematic review and meta-analysis of the effects of menopause hormone therapy on cognition.Frontiers in endocrinology · 2024Pooled it
- Systematic review ofFrontiers in aging neuroscience · 2023Pooled it
- Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer's disease and dementia.Frontiers in aging neuroscience · 2023Pooled it
- Behavior Change Techniques in Digital Health Interventions for Midlife Women: Systematic Review.JMIR mHealth and uHealth · 2022Pooled it
- Lifespan exposure to hormone therapies and structural brain morphometry in older women.NeuroImage · 2026Trial
- Sex- and age-related shift of relapse phenotypes in a cohort of relapsing multiple sclerosis patients: Post hoc analysis from the OPERA phase 3 trials.European journal of neurology · 2024Trial
- Report of the FDA's expert panel on hormone therapy.Menopause (New York, N.Y.) · 2026Review
- Genetic links between female reproductive milestones and major depressive disorder: evidence from a common genetic factor model.Archives of women's mental health · 2026Article
- Progressive hypothalamic neuroinflammation in ovariectomized mice parallels aging-related transcriptomic changes in the female human hypothalamus.JCI insight · 2026Article
- Mapping ovarian cellular and molecular landscape across the lifespan of women: a scoping review.Human reproduction update · 2026Article
- Pharmacological maintenance treatment in older age bipolar disorder.Current opinion in psychiatry · 2026Review
- Association between reproductive history, white matter integrity, and cognition in post-menopausal Latina women from the Boston Latino Aging Study.Journal of clinical and experimental neuropsychology · 2026Observational
- Menopause and neurological disorders: a roadmap for research.Nature reviews. Neurology · 2026Review
- Metabolic Changes of Perimenopause and Nutritional Advice.Current nutrition reports · 2026Review
- Age at Menopause and Brain Atrophy Among Older Women.JAMA network open · 2026Article
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- Hormone replacement therapy and dementia risk among postmenopausal women: Identifying responsive subgroups in the UK Biobank.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Menopausal insomnia as a modifiable node of dementia risk: Mechanistic insights and intervention strategies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Distinct intrinsic neural connectivity of an emotion regulation network across the menopausal transition.Comprehensive psychoneuroendocrinology · 2026Article
250 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Perimenopause is a midlife transition state experienced by women that occurs in the context of a fully functioning neurological system and results in reproductive senescence. Although primarily viewed as a reproductive transition, the symptoms of perimenopause are largely neurological in nature. Neurological symptoms that emerge during perimenopause are indicative of disruption in multiple estrogen-regulated systems (including thermoregulation, sleep, circadian rhythms and sensory processing) and affect multiple domains of cognitive function. Estrogen is a master regulator that functions through a network of estrogen receptors to ensure that the brain effectively responds at rapid, intermediate and long timescales to regulate energy metabolism in the brain via coordinated signalling and transcriptional pathways. The estrogen receptor network becomes uncoupled from the bioenergetic system during the perimenopausal transition and, as a corollary, a hypometabolic state associated with neurological dysfunction can develop. For some women, this hypometabolic state might increase the risk of developing neurodegenerative diseases later in life. The perimenopausal transition might also represent a window of opportunity to prevent age-related neurological diseases. This Review considers the importance of neurological symptoms in perimenopause in the context of their relationship to the network of estrogen receptors that control metabolism in the brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.