ArticleMolecules (Basel, Switzerland)2015
Cellular Structural Changes in Candida albicans Caused by the Hydroalcoholic Extract from Sapindus saponaria L.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 25 citations in OpenAlex.
- Global distribution of soapberries (Sapindus L.) habitats under current and future climate scenarios.Scientific reports · 2021Article
- Green Synthesis of Silver Nanoparticles Using theACS omega · 2021Article
- Human Nails Permeation of an Antifungal Candidate Hydroalcoholic Extract from the PlantMolecules (Basel, Switzerland) · 2021Article
- Effective Inhibition of Candidiasis Using an Eco-Friendly Leaf Extract ofNanomaterials (Basel, Switzerland) · 2020Article
- Article
- Evaluation ofJournal of pharmacy & bioallied sciencesArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vulvovaginal candidiasis (VVC) is a disease caused by the abnormal growth of yeast-like fungi in the mucosa of the female genital tract. Candida albicans is the principal etiological agent involved in VVC, but reports have shown an increase in the prevalence of Candida non-C. albicans (CNCA) cases, which complicates VVC treatment because CNCA does not respond well to antifungal therapy. Our group has reported the in vitro antifungal activity of extracts from Sapindus saponaria L. The present study used scanning electron microscopy and transmission electron microscopy to further evaluate the antifungal activity of hydroalcoholic extract from S. saponaria (HE) against yeast obtained from VVC and structural changes induced by HE. We observed the antifungal activity of HE against 125 vaginal yeasts that belonged to four different species of the Candida genus and S. cerevisae. The results suggest that saponins that are present in HE act on the cell wall or membrane of yeast at the first moments after contact, causing damage to these structures and cell lysis.
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Registered trials
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