SynthesisLung2015
The Relationship of HLA-DQ Alleles with Tuberculosis Risk: A Meta-analysis.
Synthesis in Lung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Immunoinformatics Predictions on VariableMicroorganisms · 2025Article
- Article
- Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4Frontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human leukocyte antigen (HLA) system plays an important role in regulating immune response because it takes part in the defense against pathogens. Some individual research studies have demonstrated that HLA class II genes play an important role in tuberculosis (TB) in several populations. However, the results were controversial. A meta-analysis was performed to examine the associations between HLA alleles and TB risk.
methodsRelevant studies on the association of HLA-DQA1 and DQB1 alleles with TB were included in the analyses. We examined papers published in the PubMed and EMBASE databases up to June 10, 2014. The odds ratios (ORs) and 95 % confidence intervals (CI) were analyzed from fixed-effects or random-effects models. Subgroup analyses were conducted by ethnicity.
resultsThis meta-analysis included 12 studies with DQB1 (1290 TB patients and 1471 controls) and 6 studies with DQA1 (453 TB patients and 648 controls). Only DQB1*0601 was found to have a significant association with an increased risk for TB [OR (95 % CI) = 1.68 (1.32-2.14), P = 0.000]. No significant association with TB risk was found in any HLA-DQA1 allele or in other HLA-DQB1 alleles. DQB1*0601 was significantly related to an increased risk of TB in Asian group, whereas no evidence was found in the non-Asian group.
conclusionOur meta-analysis supports the hypothesis that the specific HLA-DQB1 may be regarded as a marker of real worth for predicting the risk of developing TB. The same result was shown in Asian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.