ArticleNature communications2015
Orbitofrontal lesions eliminate signalling of biological significance in cue-responsive ventral striatal neurons.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cortical-subcortical interactions in goal-directed behavior.Physiological reviews · 2023Review
- Orbitofrontal control of visual cortex gain promotes visual associative learning.Nature communications · 2020Article
- Learning, memory and consolidation mechanisms for behavioral control in hierarchically organized cortico-basal ganglia systems.Hippocampus · 2020Review
- Rethinking dopamine as generalized prediction error.Proceedings. Biological sciences · 2018Article
- Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens.Nature communications · 2018Article
- Article
- Selective Modulation of Orbitofrontal Network Activity during Negative Occasion Setting.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Suppression of Ventral Hippocampal Output Impairs Integrated Orbitofrontal Encoding of Task Structure.Neuron · 2017Article
- Orbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine.Neuropharmacology · 2017Article
- Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex.Nature reviews. Neuroscience · 2016Review
- Elucidating neural network functional connectivity abnormalities in bipolar disorder: toward a harmonized methodological approach.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
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Authors and funding
7 authors.
Funding
Abstract
The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-unit activity from ventral striatum core in rats with sham or ipsilateral neurotoxic lesions of lateral OFC, as they performed an odour-guided spatial choice task. Consistent with prior reports, we found that spiking activity recorded in sham rats during cue sampling was related to both reward magnitude and reward identity, with higher firing rates observed for cues that predicted more reward. Lesioned rats also showed differential activity to the cues, but this activity was unbiased towards larger rewards. These data support a role for OFC in shaping activity in the ventral striatum to represent the biological significance of associative information in the environment.
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