Evidence map›Paper›PMID 26005999›Full record

ArticleNature nanotechnology2015

Prescribed nanoparticle cluster architectures and low-dimensional arrays built using octahedral DNA origami frames.

Ye Tian, Tong Wang, Wenyan Liu, Huolin L Xin, Huilin Li, Yonggang Ke, William M Shih, Oleg Gang

Abstract read
In one paragraph

Article in Nature nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Chiral Plasmonic Crystals Self-Assembled by DNA Origami.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Mesoscience in Hollow Multi-Shelled Structures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  12. Controlling Silicification on DNA Origami with Polynucleotide Brushes.Journal of the American Chemical Society · 2024
    Article
  13. Programming the morphology of DNA origami crystals by magnesium ion strength.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ye TianCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA.
Tong WangBiosciences Department, Brookhaven National Laboratory, Upton, New York 11973, USA.
Wenyan LiuCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA.
Huolin L XinCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA.ORCID 000000026521868X
Huilin Li1] Biosciences Department, Brookhaven National Laboratory, Upton, New York 11973, USA [2] Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794-5213, USA.
Yonggang Ke1] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [3] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.
William M Shih1] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [3] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.
Oleg GangCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA.

Funding

Structure Biology of Mycobacterium Tuberculosis Pup-Proteasome PathwayR01AI070285 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI LI, HUILIN · 2007 to 2022
$6.5M
Structural mechanism of DNA replicationR35GM131754 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI Huilin Li · 2019 to 2026
$6.0M
Gamma-Secretase: Structure of an Intramembrane ProteaseR01AG029979 · NIA · VAN ANDEL RESEARCH INSTITUTE · PI LI, HUILIN · 2011 to 2015
$1.9M
Structural Basis of Eukaryotic Replication Initiation by Cryo-EMR01GM111742 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI LI, HUILIN · 2015 to 2018
$1.4M
CCD Camera for Cryo-EMS10RR025415 · NCRR · STATE UNIVERSITY NEW YORK STONY BROOK · PI LI, HUILIN · 2009 to 2009
$244k
NCRR NIH HHS S10 RR025415NIAID NIH HHS R01 AI070285NIA NIH HHS R01 AG029979NIGMS NIH HHS R01 GM111742NIGMS NIH HHS R35 GM131754
6 · The paper itself

Abstract

Three-dimensional mesoscale clusters that are formed from nanoparticles spatially arranged in pre-determined positions can be thought of as mesoscale analogues of molecules. These nanoparticle architectures could offer tailored properties due to collective effects, but developing a general platform for fabricating such clusters is a significant challenge. Here, we report a strategy for assembling three-dimensional nanoparticle clusters that uses a molecular frame designed with encoded vertices for particle placement. The frame is a DNA origami octahedron and can be used to fabricate clusters with various symmetries and particle compositions. Cryo-electron microscopy is used to uncover the structure of the DNA frame and to reveal that the nanoparticles are spatially coordinated in the prescribed manner. We show that the DNA frame and one set of nanoparticles can be used to create nanoclusters with different chiroptical activities. We also show that the octahedra can serve as programmable interparticle linkers, allowing one- and two-dimensional arrays to be assembled with designed particle arrangements.

Indexed as

Printing, Three-DimensionalCrystallizationDNAMaterials TestingNanocompositesNucleic Acid ConformationParticle SizeDNA

Identifiers

PMID26005999
PMCPMC5282466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.