ArticleNature genetics2015
A cascade of arabinosyltransferases controls shoot meristem size in tomato.
Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers.
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Who cites it
221 citing papers in PubMed, 493 citations in OpenAlex.
- Meristem size drives merism lability in the Hexandrum group, a highly variable lineage of Solanum (Solanaceae).Journal of plant research · 2026Article
- Multi-variant GWAS and genomic prediction dissect the genetic architecture underlying tomato fruit weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A disulfide bond sculpts the CTNIP4 phytocytokine fold for recognition by the receptor kinase HSL3.Nature plants · 2026Article
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Natural and CRISPR/Cas9 Editing Variations of Dual-uORFs Synergistically Increase the Nutritional Value of Silage Maize Feed.Plant biotechnology journal · 2026Article
- Natural variation in SlGRF10 reveals a role in regulating tomato fruit weight.Plant physiology · 2026Article
- Protein Phosphorylation: An Essential Role in Shoot Apical Meristem Homeostasis.Plants (Basel, Switzerland) · 2026Review
- Review
- Fine mapping and transcriptomic analysis reveal BnaMMS, a novel locus regulating multi-main-stem phenotype via auxin pathway in rapeseed.BMC plant biology · 2026Article
- Rare Natural SNP Activates SHOOT APICAL MERISTEM ENLARGER1 to Increase Branch Number and Silique Number on the Main Inflorescence in Brassica napus.Plant biotechnology journal · 2026Article
- The G protein-casein kinase 2 module acts as a pivot in plasma membrane-to-nucleus CLAVATA signaling to control shoot apical meristem size.Nature communications · 2026Article
- WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Reproductive Diversity in Cultivated Tomato (Plants (Basel, Switzerland) · 2026Article
- Haplotype-based genome-wide association study uncovers QTL for fruit-related traits in the 287 tomato accessions.BMC plant biology · 2026Article
- Integrated high-density genetic maps in multi-parent FBMC plant biology · 2026Article
- Fruit weight regulation by a paralog of Cell Size Regulator (CSR) in tomato and other crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Developmental diversity in meristem organization: lessons from non-canonical plant body plans for biotechnology.Frontiers in plant science · 2026Review
- Regulatory layers of robustness of CLAVATA-WUSCHEL feedback system in stem cell homeostasis.Frontiers in plant science · 2026Review
- Virus-mediated, heritable gene editing in groundcherry (Frontiers in plant science · 2026Article
- TheForestry research · 2026Article
161 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shoot meristems of plants are composed of stem cells that are continuously replenished through a classical feedback circuit involving the homeobox WUSCHEL (WUS) gene and the CLAVATA (CLV) gene signaling pathway. In CLV signaling, the CLV1 receptor complex is bound by CLV3, a secreted peptide modified with sugars. However, the pathway responsible for modifying CLV3 and its relevance for CLV signaling are unknown. Here we show that tomato inflorescence branching mutants with extra flower and fruit organs due to enlarged meristems are defective in arabinosyltransferase genes. The most extreme mutant is disrupted in a hydroxyproline O-arabinosyltransferase and can be rescued with arabinosylated CLV3. Weaker mutants are defective in arabinosyltransferases that extend arabinose chains, indicating that CLV3 must be fully arabinosylated to maintain meristem size. Finally, we show that a mutation in CLV3 increased fruit size during domestication. Our findings uncover a new layer of complexity in the control of plant stem cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.