Evidence map›Paper›PMID 26005852›Full record

ArticleNature neuroscience2015

The schizophrenia risk gene product miR-137 alters presynaptic plasticity.

Sandra Siegert, Jinsoo Seo, Ester J Kwon, Andrii Rudenko, Sukhee Cho, Wenyuan Wang, Zachary Flood, Anthony J Martorell, Maria Ericsson, Alison E Mungenast and 1 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 131 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 1 synthesis or guideline pooled it, 229 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. MicroRNAs and synaptic dysfunction in Parkinson's disease.Molecular therapy. Nucleic acids · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Small Differences and Big Changes: The Many Variables of MicroRNA Expression and Function in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  16. Article
  17. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
  19. miR-137: a potential therapeutic target for lung cancer.Frontiers in cell and developmental biology · 2024
    Review
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sandra Siegert1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Jinsoo Seo1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Ester J Kwon1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Andrii Rudenko1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Sukhee Cho1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Wenyuan Wang1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Zachary Flood1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Anthony J Martorell1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Maria EricssonDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Alison E Mungenast1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA.
Li-Huei Tsai1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA. [3] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Massachusetts Institute of Technology · USBroad Institute · USHarvard University · US

Funding

Chemical Genomic Approaches to Neurobiology of DISC1R01MH091115 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2010 to 2014
$3.4M
NIMH NIH HHS R01 MH 091115NIMH NIH HHS R01 MH091115
6 · The paper itself

Abstract

Noncoding variants in the human MIR137 gene locus increase schizophrenia risk with genome-wide significance. However, the functional consequence of these risk alleles is unknown. Here we examined induced human neurons harboring the minor alleles of four disease-associated single nucleotide polymorphisms in MIR137. We observed increased MIR137 levels compared to those in major allele-carrying cells. microRNA-137 gain of function caused downregulation of the presynaptic target genes complexin-1 (Cplx1), Nsf and synaptotagmin-1 (Syt1), leading to impaired vesicle release. In vivo, miR-137 gain of function resulted in changes in synaptic vesicle pool distribution, impaired induction of mossy fiber long-term potentiation and deficits in hippocampus-dependent learning and memory. By sequestering endogenous miR-137, we were able to ameliorate the synaptic phenotypes. Moreover, reinstatement of Syt1 expression partially restored synaptic plasticity, demonstrating the importance of Syt1 as a miR-137 target. Our data provide new insight into the mechanism by which miR-137 dysregulation can impair synaptic plasticity in the hippocampus.

Indexed as

Adaptor Proteins, Vesicular TransportAllelesAnimalsBehavior, AnimalDisease Models, AnimalFibroblastsGene Expression RegulationGenetic LociHEK293 CellsHumansLearningLong-Term PotentiationMiceMice, Inbred C57BLMicroRNAsMossy Fibers, HippocampalAdaptor Proteins, Vesicular Transportcomplexin IMicroRNAsMIRN137 microRNA, humanMIRN137 microRNA, mouseNerve Tissue ProteinsN-Ethylmaleimide-Sensitive ProteinsSynaptotagmin I

Identifiers

PMID26005852
PMCPMC4506960
OpenAlexW1533589220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.