ArticleNature neuroscience2015
Experience-dependent DNA methylation regulates plasticity in the developing visual cortex.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Epigenetic mechanisms of inflammatory memory in the central nervous system.Nature immunology · 2026Review
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- MicroRNA-29 acutely regulates memory stability, expression of synaptic genes, and DNA methylation in the mouse adult hippocampus.Cellular and molecular life sciences : CMLS · 2026Article
- Single-cell sequencing reveals reversible glial remodeling in the visual cortex during visual deprivation and recovery.Frontiers in immunology · 2026Article
- Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy.Human genomics · 2025Observational
- Neurodevelopmental Disorders Associated with Gut Microbiome Dysbiosis in Children.Children (Basel, Switzerland) · 2024Review
- Methylation in cornea and corneal diseases: a systematic review.Cell death discovery · 2024Review
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- Epigenetic MRI: Noninvasive imaging of DNA methylation in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- DNA Methylation-Dependent Gene Expression Regulation of Glutamate Transporters in Cultured Radial Glial Cells.Molecular neurobiology · 2022Article
- Non-Cell-Autonomous Factors Implicated in Parvalbumin Interneuron Maturation and Critical Periods.Frontiers in neural circuits · 2022Review
- MicroRNAs in the Onset of Schizophrenia.Cells · 2021Review
- Article
- Review
- Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus.Epigenetics & chromatin · 2019Article
- The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression.Cancer research · 2017Article
- TET-mediated active DNA demethylation: mechanism, function and beyond.Nature reviews. Genetics · 2017Review
- Bi-directional and shared epigenomic signatures following proton andScientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is an epigenetic repressor mark for transcription dynamically regulated in neurons. We analyzed visual experience regulation of DNA methylation in mice and its involvement in ocular dominance plasticity of the developing visual cortex. Monocular deprivation modulated the expression of factors controlling DNA methylation and exerted opposite effects on DNA methylation and hydroxymethylation in specific plasticity genes. Inhibition of DNA methyltrasferase (DNMT) blocked molecular and functional effects of monocular deprivation, partially reversing the monocular deprivation transcriptional program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.