ArticleInternational journal of cancer and clinical research
Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity.
Article in International journal of cancer and clinical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Review
- Article
- DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women.Basic & clinical pharmacology & toxicology · 2020Article
- Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation.British journal of pharmacology · 2020Review
- Prediagnosis aspirin use, DNA methylation, and mortality after breast cancer: A population-based study.Cancer · 2019Article
- Disadvantaged neighborhoods and racial disparity in breast cancer outcomes: the biological link.Cancer causes & control : CCC · 2019Review
- Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues.Breast cancer research and treatment · 2019Article
- Modification of the association between recreational physical activity and survival after breast cancer by promoter methylation in breast cancer-related genes.Breast cancer research : BCR · 2017Article
- The most important questions in cancer research and clinical oncology-Question 2-5. Obesity-related cancers: more questions than answers.Chinese journal of cancer · 2017Article
- Rotating night work, lifestyle factors, obesity and promoter methylation in BRCA1 and BRCA2 genes among nurses and midwives.PloS one · 2017Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
introductionBreast cancer, the leading cancer diagnosis among American women, is positively associated with postmenopausal obesity and little or no recreational physical activity (RPA). However, the underlying mechanisms of these associations remain unresolved. Aberrant changes in DNA methylation may represent an early event in carcinogenesis, but few studies have investigated associations between obesity/RPA and gene methylation, particularly in postmenopausal breast tumors where these lifestyle factors are most relevant.
methodsWe used case-case unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the associations between body mass index (BMI=weight [kg]/height [m
resultsBMI 25-29.9kg/m DISCUSSION: While biologically plausible, our findings that BMI is associated with methylated
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