ArticleJournal of ophthalmic & vision research
Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers.
Article in Journal of ophthalmic & vision research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- [Corneal melting under PD-1/PD-L1 inhibition].Die Ophthalmologie · 2026Article
- Comparison of Collagen Cross-Linking Alone to 1% Povidone-Iodine Treatment of Refractory Corneal Ulcers: A Randomized Clinical Trial.Journal of ophthalmology · 2025Article
- Photoactivated Chromophore Corneal Collagen Cross-Linking for Infectious Keratitis (PACK-CXL)-A Comprehensive Review of Diagnostic and Prognostic Factors Involved in Therapeutic Indications and Contraindications.Journal of personalized medicine · 2022Review
- Surgical treatment of canine and feline descemetoceles, deep and perforated corneal ulcers with autologous buccal mucous membrane grafts.Veterinary ophthalmology · 2021Article
- An Assay System to Evaluate Riboflavin/UV-A Corneal Phototherapy Efficacy in a Porcine Corneal Organ Culture Model.Animals : an open access journal from MDPI · 2020Article
- Long-term outcomes of riboflavin photodynamic antimicrobial therapy as a treatment for infectious keratitis.American journal of ophthalmology case reports · 2019Article
- Changes in interleukin-6 tear concentration and clinical outcome in moderate-to-severe bacterial corneal ulcers after corneal collagen cross-linking.International journal of ophthalmology · 2018Article
- Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis.Journal of clinical and diagnostic research : JCDR · 2017Article
- Corneal collagen cross-linking and liposomal amphotericin B combination therapy for fungal keratitis in rabbits.International journal of ophthalmology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy.
methodsEight patients with corneal ulcers associated with corneal melting, not responding to conventional antibiotic therapy, were treated with CXL. The procedure was performed according to the standardized protocol for keratoconus. Preoperative medications were continued after CXL in all cases. Microbiological exams revealed Pseudomonas aeruginosa in 3 cases. Follow up continued from 1 to 10 months.
resultsIn 6 of 8 eyes, progression of corneal melting was halted and complete epithelialization occurred. In one eye emergency keratoplasty was needed due to corneal perforation. A conjunctival flap was performed to treat severe localized corneal thinning in one of the patients a few days after CXL. Significant clinical improvement occurred in all cases of Pseudomonas aeruginosa keratitis.
conclusionCXL can be considered as a promising new treatment in the management of refractory non-healing corneal ulcers, including Pseudomonas aeruginosa keratitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.