Evidence map›Paper›PMID 26005422›Full record

ReviewFrontiers in physiology2015

Structural determinants of criticality in biological networks.

Sergi Valverde, Sebastian Ohse, Malgorzata Turalska, Bruce J West, Jordi Garcia-Ojalvo

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Criticality in cell differentiation.Journal of biosciences · 2017
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sergi ValverdeICREA-Complex Systems Lab, Universitat Pompeu Fabra Barcelona, Spain ; Institute of Evolutionary Biology (CSIC-UPF), Universitat Pompeu Fabra Barcelona, Spain.
Sebastian OhseInstitute of Molecular Medicine and Cell Research, Albert-Ludwigs-Universität Freiburg Freiburg, Germany.
Malgorzata TuralskaDepartment of Physics, Duke University Durham, NC, USA.
Bruce J WestDepartment of Physics, Duke University Durham, NC, USA ; Mathematical and Information Sciences Directorate, U.S. Army Research Office, Research Triangle Park NC, USA.
Jordi Garcia-OjalvoDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many adaptive evolutionary systems display spatial and temporal features, such as long-range correlations, typically associated with the critical point of a phase transition in statistical physics. Empirical and theoretical studies suggest that operating near criticality enhances the functionality of biological networks, such as brain and gene networks, in terms for instance of information processing, robustness, and evolvability. While previous studies have explained criticality with specific system features, we still lack a general theory of critical behavior in biological systems. Here we look at this problem from the complex systems perspective, since in principle all critical biological circuits have in common the fact that their internal organization can be described as a complex network. An important question is how self-similar structure influences self-similar dynamics. Modularity and heterogeneity, for instance, affect the location of critical points and can be used to tune the system toward criticality. We review and discuss recent studies on the criticality of neuronal and genetic networks, and discuss the implications of network theory when assessing the evolutionary features of criticality.

Indexed as

criticalityevolutiongene regulatory networkshierarchical modular networksneural networkspower lawsrobustness

Identifiers

PMID26005422
PMCPMC4424853

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.