Evidence map›Paper›PMID 26004847›Full record

ArticleJournal of neuroscience methods2015

Potential of N-acetylated-para-aminosalicylic acid to accelerate manganese enhancement decline for long-term MEMRI in rodent brain.

Aditya N Bade, Biyun Zhou, JoEllyn McMillan, Prabagaran Narayanasamy, Ram Veerubhotla, Howard E Gendelman, Michael D Boska, Yutong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Aditya N BadeDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, United States.
Biyun ZhouDepartment of Anesthesiology, Tongji Medical College, Huanzhong University of Science and Technology, China.
JoEllyn McMillanDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, United States.
Prabagaran NarayanasamyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, United States; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, United States.
Ram VeerubhotlaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, United States.
Howard E GendelmanDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, United States.
Michael D BoskaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, United States; Department of Radiology, University of Nebraska Medical Center, Omaha, NE, 68198-1045, United States.
Yutong LiuDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5800, United States; Department of Radiology, University of Nebraska Medical Center, Omaha, NE, 68198-1045, United States. Electronic address: yutongliu@unmc.edu.
University of Nebraska Medical Center · USHuazhong University of Science and Technology · CN

Funding

Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2000 to 2021
$37.7M
Pharmacokinetics and Drug-Drug InteractionsP01DA028555 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ALNOUTI, YAZEN · 2010 to 2019
$16.8M
Nanomedicine and NeuroAIDSR01NS036126 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 1997 to 2017
$5.7M
SMART HANDR01AG043540 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E, POLUEKTOVA, LARISA Y · 2013 to 2017
$3.1M
Manganese Enhanced Multi-MRI for Murine HIV-1 Associated Neurocognitive DisordersK25MH089851 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LIU, YUTONG · 2010 to 2014
$723k
NIA NIH HHS R01 AG043540NIDA NIH HHS P01 DA028555NIMH NIH HHS 1K25 MH089851NIMH NIH HHS K25 MH089851NIMH NIH HHS P30 MH062261NINDS NIH HHS R01 NS036126
6 · The paper itself

Abstract

backgroundManganese (Mn(2+))-enhanced MRI (MEMRI) is a valuable imaging tool to study brain structure and function in normal and diseased small animals. The brain retention of Mn(2+) is relatively long with a half-life (t1/2) of 51-74 days causing a slow decline of MRI signal enhancement following Mn(2+) administration. Such slow decline limits using repeated MEMRI to follow the central nervous system longitudinally in weeks or months. This is because residual Mn(2+) from preceding administrations can confound the interpretation of imaging results. We investigated whether the Mn(2+) enhancement decline could be accelerated thus enabling repeated MEMRI, and as a consequence broadens the utility of MEMRI tests. NEW

methodsWe investigated whether N-acetyl-para-aminosalicylic acid (AcPAS), a chelator of Mn(2+), could affect the decline of Mn(2+) induced MRI enhancement in brain. RESULTS AND

conclusionTwo-week treatment with AcPAS (200mg/kg/dose×3 daily) accelerated the decline of Mn(2+) induced enhancement in MRI. In the whole brain on average the enhancement declined from 100% to 17% in AcPAS treated mice, while in PBS controls the decline is from 100% to 27%. We posit that AcPAS could enhance MEMRI utility for evaluating brain biology in small animals. COMPARISON WITH EXISTING

methodsTo the best of our knowledge, no method exists to accelerate the decline of the Mn(2+) induced MRI enhancement for repeated MEMRI tests.

Indexed as

Brain MappingMagnetic Resonance ImagingAminosalicylic AcidsAnimalsBrainChloridesChromatography, High Pressure LiquidDrug SynergismImage Processing, Computer-AssistedManganese CompoundsMiceMice, Inbred C57BLTime Factorsacetyl 4-aminosalicylic acidAminosalicylic AcidsChloridesmanganese chlorideManganese CompoundsChelationManganese enhanced MRI (MEMRI)N-acetylated-para-aminosalicylic acid (AcPAS)Repeated MEMRI

Identifiers

PMID26004847
PMCPMC4500662
OpenAlexW321592570

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.