Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2015
Clinical Predictors of Response to Cognitive-Behavioral Therapy in Pediatric Anxiety Disorders: The Genes for Treatment (GxT) Study.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03062891 (Sleep Treatment Outcome Predictors), which is not on this map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep Treatment Outcome Predictors: A Pilot Study (STOP-pilot)
Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- The effect of social anxiety on threat acquisition and extinction: a systematic review and meta-analysis.PeerJ · 2024Pooled it
- The Effectiveness of Psychological Therapies for Anxiety Disorders in Adolescents: A Meta-Analysis.Clinical child and family psychology review · 2021Pooled it
- Are young people with primary social anxiety disorder less likely to recover following generic CBT compared to young people with other primary anxiety disorders? A systematic review and meta-analysis.Behavioural and cognitive psychotherapy · 2021Pooled it
- A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders.Translational psychiatry · 2019Pooled it
- Comparison of Disorder-Specific Group CBT and Generic Group CBT in Treating Adolescents with Social Anxiety Disorder: A Randomized Controlled Trial.Research on child and adolescent psychopathology · 2026Trial
- Implications of cooccurring ADHD for the cognitive behavioural treatment of anxiety in autistic children.Journal of child psychology and psychiatry, and allied disciplines · 2025Trial
- Predictors and Moderators of Treatment Outcomes for Anxious Children Randomized to Computer-Assisted Cognitive Behavioral Therapy or Standard Community Care.Journal of child and adolescent psychopharmacology · 2023Trial
- Moderators of Response to Personalized and Standard Care Cognitive-Behavioral Therapy for Youth with Autism Spectrum Disorder and Comorbid Anxiety.Journal of autism and developmental disorders · 2022Trial
- A randomised controlled trial of treatments of childhood anxiety disorder in the context of maternal anxiety disorder: clinical and cost-effectiveness outcomes.Journal of child psychology and psychiatry, and allied disciplines · 2020Trial
- Attention Bias Modification Treatment for Adolescents With Social Anxiety Disorder.Behavior therapy · 2019Trial
- Transgenerational improvements following child anxiety treatment: An exploratory examination.PloS one · 2019Trial
- Trial
- Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.The British journal of psychiatry : the journal of mental science · 2016Trial
- Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.The British journal of psychiatry : the journal of mental science · 2016Trial
- Refining Clinical Judgment of Treatment Response and Symptom Remission Identification in Childhood Anxiety Using a Signal Detection Analysis on the Pediatric Anxiety Rating Scale.Journal of child and adolescent psychopharmacology · 2015Trial
- How Many Anxious Kids in Community Mental Health Would Be Eligible for an RCT? And Does It Matter? Insights from a Naturalistic Sample and a Non-Systematic Review.Children (Basel, Switzerland) · 2026Article
- Evaluating the efficacy of psychological therapies for generalised anxiety disorder in children and adolescents: A systematic review and narrative synthesis.JCPP advances · 2026Article
- Who Benefits Most? Predictors of Treatment Response in Group Interventions for Children's Emotional Disorders.Child psychiatry and human development · 2025Article
- Targeting neurobehavioral substrates of effortful control to reduce childhood anxiety: The Camp Kidpower study protocol.Research square · 2025Article
- Therapeutic Processes that Impact Child Outcomes Following Exposure Therapy for Child Specific Phobias.Child psychiatry and human development · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 13 institutions in 8 countries.
Funding
Abstract
objectiveThe Genes for Treatment study is an international, multisite collaboration exploring the role of genetic, demographic, and clinical predictors in response to cognitive-behavioral therapy (CBT) in pediatric anxiety disorders. The current article, the first from the study, examined demographic and clinical predictors of response to CBT. We hypothesized that the child's gender, type of anxiety disorder, initial severity and comorbidity, and parents' psychopathology would significantly predict outcome.
methodA sample of 1,519 children 5 to 18 years of age with a primary anxiety diagnosis received CBT across 11 sites. Outcome was defined as response (change in diagnostic severity) and remission (absence of the primary diagnosis) at each time point (posttreatment, 3-, 6-, and/or 12-month follow-up) and analyzed using linear and logistic mixed models. Separate analyses were conducted using data from posttreatment and follow-up assessments to explore the relative importance of predictors at these time points.
resultsIndividuals with social anxiety disorder (SoAD) had significantly poorer outcomes (poorer response and lower rates of remission) than those with generalized anxiety disorder (GAD). Although individuals with specific phobia (SP) also had poorer outcomes than those with GAD at posttreatment, these differences were not maintained at follow-up. Both comorbid mood and externalizing disorders significantly predicted poorer outcomes at posttreatment and follow-up, whereas self-reported parental psychopathology had little effect on posttreatment outcomes but significantly predicted response (although not remission) at follow-up.
conclusionSoAD, nonanxiety comorbidity, and parental psychopathology were associated with poorer outcomes after CBT. The results highlight the need for enhanced treatments for children at risk for poorer outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.