ArticleStem cell reports2015
Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.
Article in Stem cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Functional Validation of Alcohol Dependence-AssociatedInternational journal of stem cells · 2025Article
- GenomicLayers: sequence-based simulation of epi-genomes.BMC bioinformatics · 2025Article
- DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells.Nature communications · 2024Article
- Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential.Cellular reprogramming · 2024Article
- Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant.Cell death & disease · 2023Article
- Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges.Brain sciences · 2023Review
- Single-Cell Transcriptome Analysis as a Promising Tool to Study Pluripotent Stem Cell Reprogramming.International journal of molecular sciences · 2021Review
- Reply to Cattoretti: Specificity of anti-MYC antibodies.The Journal of biological chemistry · 2020Article
- Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.Nature communications · 2018Article
- Time-course transcriptome analysis of human cellular reprogramming from multiple cell types reveals the drastic change occurs between the mid phase and the late phase.BMC genomics · 2018Article
- Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells.Nucleic acids research · 2017Article
- EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression.Molecular cancer · 2017Review
- Systematic evaluation of markers used for the identification of human induced pluripotent stem cells.Biology open · 2017Article
- Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming.RNA (New York, N.Y.) · 2016Article
- TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells.Stem cells international · 2016Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Reprogramming of somatic cells produces induced pluripotent stem cells (iPSCs) that are invaluable resources for biomedical research. Here, we extended the previous transcriptome studies by performing RNA-seq on cells defined by a combination of multiple cellular surface markers. We found that transcriptome changes during early reprogramming occur independently from the opening of closed chromatin by OCT4, SOX2, KLF4, and MYC (OSKM). Furthermore, our data identify multiple spliced forms of genes uniquely expressed at each progressive stage of reprogramming. In particular, we found a pluripotency-specific spliced form of CCNE1 that is specific to human and significantly enhances reprogramming. In addition, single nucleotide polymorphism (SNP) expression analysis reveals that monoallelic gene expression is induced in the intermediate stages of reprogramming, while biallelic expression is recovered upon completion of reprogramming. Our transcriptome data provide unique opportunities in understanding human iPSC reprogramming.
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Registered trials
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