ArticleResearch in microbiology
Host adaption to the bacteriophage carrier state of Campylobacter jejuni.
Article in Research in microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Effects of bacteriophages on gut microbiome functionality.Gut microbes · 2025Review
- Provirus deletion frommicroLife · 2025Article
- Black box of phage-bacterium interactions: exploring alternative phage infection strategies.Open biology · 2021Review
- Application ofAnimals : an open access journal from MDPI · 2020Review
- Review
- Phage Biocontrol ofFrontiers in microbiology · 2019Article
- FlhF(T368A) modulates motility in the bacteriophage carrier state of Campylobacter jejuni.Molecular microbiology · 2018Article
- Transcriptomic Analysis of theViruses · 2018Article
- Review
- Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168.Nucleic acids research · 2016Article
- The Minor Flagellin ofFrontiers in microbiology · 2016Article
- The Bacteriophage Carrier State of Campylobacter jejuni Features Changes in Host Non-coding RNAs and the Acquisition of New Host-derived CRISPR Spacer Sequences.Frontiers in microbiology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The carrier state of the foodborne pathogen Campylobacter jejuni represents an alternative life cycle whereby virulent bacteriophages can persist in association with host bacteria without commitment to lysogeny. Host bacteria exhibit significant phenotypic changes that improve their ability to survive extra-intestinal environments, but exhibit growth-phase-dependent impairment in motility. We demonstrate that early exponential phase cultures become synchronised with respect to the non-motile phenotype, which corresponds with a reduction in their ability to adhere to and invade intestinal epithelial cells. Comparative transcriptome analyses (RNA-seq) identify changes in gene expression that account for the observed phenotypes: downregulation of stress response genes hrcA, hspR and per and downregulation of the major flagellin flaA with the chemotactic response signalling genes cheV, cheA and cheW. These changes present mechanisms by which the host and bacteriophage can remain associated without lysis, and the cultures survive extra-intestinal transit. These data provide a basis for understanding a critical link in the ecology of the Campylobacter bacteriophage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.