Evidence map›Paper›PMID 26004263›Full record

ReviewArchives of medical research2015

Infection and Atherosclerosis Development.

Lee Ann Campbell, Michael E Rosenfeld

Open access · greenAbstract readReview
In one paragraph

Review in Archives of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 3 syntheses or guidelines pooled it, 185 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Medicina (Kaunas, Lithuania) · 2026
    Article
  5. The Bacterial, Viral, and Microbiome Contributions in Cardiovascular Diseases: A Narrative Review.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Metagenomic Study of the MESA: Detection ofJournal of the American Heart Association · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Mathematical model of aging in COVID-19.Journal of medical biochemistry · 2023
    Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lee Ann CampbellDepartment of Epidemiology, School of Public Health, Seattle, Washington, USA. Electronic address: lacamp@uw.edu.
Michael E RosenfeldDepartments of Environmental, Health and Occupational Sciences and Pathology, University of Washington, Seattle, Washington, USA.
Public Health – Seattle & King County · USUniversity of Washington · US

Funding

CHLAMYDIA PNEUMONIAE ANTIGENS OF BIOLOGICAL SIGNIFICANCER01AI043060 · NIAID · UNIVERSITY OF WASHINGTON · PI CAMPBELL, LEE ANN · 1998 to 2012
$4.1M
NIAID NIH HHS R01 AI043060NIAID NIH HHS R01 AI43060
6 · The paper itself

Abstract

Atherosclerosis is a chronic disease hallmarked by chronic inflammation, endothelial dysfunction and lipid accumulation in the vasculature. Although lipid modification and deposition are thought to be a major source of the continuous inflammatory stimulus, a large body of evidence suggests that infectious agents may contribute to atherosclerotic processes. This could occur by either direct effects through infection of vascular cells and/or through indirect effects by induction of cytokine and acute phase reactant proteins by infection at other sites. Multiple bacterial and viral pathogens have been associated with atherosclerosis by seroepidemiological studies, identification of the infectious agent in human atherosclerotic tissue, and experimental studies demonstrating an acceleration of atherosclerosis following infection in animal models of atherosclerosis. This review will focus on those infectious agents for which biological plausibility has been demonstrated in animal models and on the challenges of proving a role of infection in human atherosclerotic disease.

Indexed as

AnimalsAtherosclerosisChronic DiseaseDisease Models, AnimalEndothelium, VascularHumansInflammationLipid MetabolismAntibiotic trialsAtherosclerosisChlamydia pneumoniaeInfectious agentsPeriodontal pathogens

Identifiers

PMID26004263
PMCPMC4524506
OpenAlexW1837456407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.