ArticleJournal of molecular biology2015
Folding Optimization In Vivo Uncovers New Chaperones.
Article in Journal of molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Severe Restriction of Glucose Import Enhances Recombinant Protein Production in Escherichia coli.Biotechnology journal · 2026Article
- Protein profile of the Escherichia coli strain, BW25113, exposed to two novel iron-halide compounds: Fe(Hampy)2Cl4 and Fe(Hampy)2Br4.Access microbiology · 2025Article
- SAS: Split antibiotic selection for identifying chaperones that improve protein solubility.Heliyon · 2024Article
- An intein-based biosensor to measure protein stability in vivo.Protein science : a publication of the Protein Society · 2024Article
- Hfq protein and GcvB small RNA tailoring ofRNA biology · 2023Article
- Transcriptomic Analysis Revealed Antimicrobial Mechanisms ofInternational journal of molecular sciences · 2022Article
- Proteome and Physiological Characterization of Halotolerant Nodule Endophytes: The Case ofMicroorganisms · 2022Article
- Microreactor equipped with naturally acid-resistant histidine ammonia lyase from an extremophile.Materials advances · 2022Article
- BonA frommBio · 2021Article
- Random and combinatorial mutagenesis for improved total production of secretory target protein in Escherichia coli.Scientific reports · 2021Article
- Stress-Responsive Periplasmic Chaperones in Bacteria.Frontiers in molecular biosciences · 2021Review
- Article
- A metabolite binding protein moonlights as a bile-responsive chaperone.The EMBO journal · 2020Article
- Identification of residues for chaperone-like activity of OppA protein in Yersinia pseudotuberculosis.AMB Express · 2020Article
- Chaperone OsmY facilitates the biogenesis of a major family of autotransporters.Molecular microbiology · 2019Article
- Oligopeptide-binding protein from nontypeableThe Journal of biological chemistry · 2019Article
- In vivo chloride concentrations surge to proteotoxic levels during acid stress.Nature chemical biology · 2018Article
- Periplasmic Chaperones and Prolyl Isomerases.EcoSal Plus · 2018Review
- Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.Nature structural & molecular biology · 2018Article
- Transcriptomic Analysis of the Swarm Motility Phenotype of Salmonella enterica Serovar Typhimurium Mutant Defective in Periplasmic Glucan Synthesis.Current microbiology · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
By employing a genetic selection that forces the cell to fold an unstable, aggregation-prone test protein in order to survive, we have generated bacterial strains with enhanced periplasmic folding capacity. These strains enhance the soluble steady-state level of the test protein. Most of the bacterial variants we isolated were found to overexpress one or more periplasmic proteins including OsmY, Ivy, DppA, OppA, and HdeB. Of these proteins, only HdeB has convincingly been previously shown to function as chaperone in vivo. By giving bacteria the stark choice between death and stabilizing a poorly folded protein, we have now generated designer bacteria selected for their ability to stabilize specific proteins.
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Registered trials
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