ArticleJournal of endocrinological investigation2015
Reduced expression of THRβ in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression.
Article in Journal of endocrinological investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- The role of miR-335-5p in the redifferentiation of BRAF p.V600E thyroid cancers.Molecular oncology · 2026Article
- The role of miR-139-5p in radioiodine-resistant thyroid cancer.Journal of endocrinological investigation · 2023Article
- Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma.International journal of molecular sciences · 2022Article
- Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Identification of Exosomal microRNAs and Their Targets in Papillary Thyroid Cancer Cells.Biomedicines · 2022Article
- The role of FOSL1 in stem-like cell reprogramming processes.Scientific reports · 2021Article
- MicroRNAs in Papillary Thyroid Cancer: What Is New in Diagnosis and Treatment.Frontiers in oncology · 2021Review
- Overexpression of modified human TRβ1 suppresses the growth of hepatocarcinoma SK-hep1 cells in vitro and in xenograft models.Molecular and cellular biochemistry · 2018Article
- Follow-up of differentiated thyroid cancer - what should (and what should not) be done.Nature reviews. Endocrinology · 2018Review
- Overexpressing modified human TRβ1 suppresses the proliferation of breast cancer MDA-MB-468 cells.Oncology letters · 2018Article
- The role of microRNAs in different types of thyroid carcinoma: a comprehensive analysis to find new miRNA supplementary therapies.Journal of endocrinological investigation · 2018Review
- Effects of nutraceuticals on anaplastic thyroid cancer cells.Journal of cancer research and clinical oncology · 2018Article
- BRAF-Oncogene-Induced Senescence and the Role of Thyroid-Stimulating Hormone Signaling in the Progression of Papillary Thyroid Carcinoma.Hormones & cancer · 2018Review
- The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review.International journal of endocrinology · 2018Review
- Association of PDCD1 gene markers with susceptibility to thyroid cancer.Journal of endocrinological investigation · 2017Article
- Key genes and pathways predicted in papillary thyroid carcinoma based on bioinformatics analysis.Journal of endocrinological investigation · 2016Article
- Molecular profiles of cancer stem-like cell populations in aggressive thyroid cancers.Endocrine · 2016Article
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11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDown-regulation of thyroid hormone receptor beta (THRβ) gene has been described in several human malignancies, including thyroid cancer. In this study, we analyzed THRβ mRNA expression in surgical specimens from a series of human papillary thyroid carcinomas (PTCs), characterized by their genotypic and clinical-biological features.
methodsThirty-six PTCs were divided into two groups according to the 2009 American Thyroid Association risk classification (17 low, 19 intermediate), and each group was divided into subgroups based on the presence or absence of the BRAFV600E mutation (21 BRAF mutated, 15 BRAF wild type). Gene expression was analyzed using fluidic cards containing probes and primers specific for the THRβ gene, as well as for genes of thyroperoxidase (TPO), sodium/iodide symporter (NIS), thyroglobulin (Tg) and thyroid stimulating hormone receptor (TSH-R) and for some miRNAs involved in thyroid neoplasia and targeting THRβ. The mRNA levels of each tumor tissue were compared with their correspondent normal counterpart.
resultsTHRβ transcript was down-regulated in all PTCs examined. No significant differences were found between intermediate- vs low-risk PTCs patients, and BRAF-mutated vs BRAF wild-type groups. THRβ expression was directly correlated with NIS, TPO, Tg and TSH-R, and inversely correlated to miR-21, -146a, -181a and -221 expression.
conclusionsOur results demonstrate that down-regulation of THRβ is a common feature of PTCs. While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis.
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