Trial reportTrials2015
PReVENT--protective ventilation in patients without ARDS at start of ventilation: study protocol for a randomized controlled trial.
Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02153294 (PRotective VENTilation in Patients Without ARDS at Start of Ventilation - PReVENT, a Randomized Controlled Trial), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PRotective VENTilation in Patients Without ARDS at Start of Ventilation - PReVENT, a Randomized Controlled Trial
Who cites it
22 citing papers in PubMed.
- Trial
- Management of non-Cardiac Organ Failure in cardiogenic shock.American heart journal plus : cardiology research and practice · 2025Article
- The PROtective VEntilation (PROVE) Network - advancing research and collaboration in mechanical ventilation.Critical care science · 2025Review
- Latest developments in early diagnosis and specific treatment of severe influenza infection.Journal of intensive medicine · 2024Review
- Observational
- Severe flu management: a point of view.Intensive care medicine · 2020Review
- Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice.Critical care (London, England) · 2019Review
- The tidal volume fix and more….Journal of thoracic disease · 2019Article
- Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.Annals of the American Thoracic Society · 2019Observational
- Pressure-regulated volume control ventilation as a means of improving lung-protective ventilation.Journal of the Intensive Care Society · 2019Article
- Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation.American journal of respiratory cell and molecular biology · 2019Article
- Optimising mechanical ventilation through model-based methods and automation.Annual reviews in control · 2019Review
- Reduction of ventilatory time using the multidisciplinary disconnection protocol. Pilot study.Revista latino-americana de enfermagem · 2019Article
- Should we titrate ventilation based on driving pressure? Maybe not in the way we would expect.Annals of translational medicine · 2018Review
- The basics of respiratory mechanics: ventilator-derived parameters.Annals of translational medicine · 2018Review
- Surviving sepsis campaign: research priorities for sepsis and septic shock.Intensive care medicine · 2018Article
- Article
- Low tidal volume ventilation use remains low in patients with acute respiratory distress syndrome at a single center.Journal of critical care · 2018Article
- Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT.Annals of intensive care · 2018Article
- Protective mechanical ventilation in United Kingdom critical care units: A multicentre audit.Journal of the Intensive Care Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is uncertain whether lung-protective mechanical ventilation using low tidal volumes should be used in all critically ill patients, irrespective of the presence of the acute respiratory distress syndrome (ARDS). A low tidal volume strategy includes use of higher respiratory rates, which could be associated with increased sedation needs, a higher incidence of delirium, and an increased risk of patient-ventilator asynchrony and ICU-acquired weakness. Another alleged side-effect of low tidal volume ventilation is the risk of atelectasis. All of these could offset the beneficial effects of low tidal volume ventilation as found in patients with ARDS. METHODS/
designPReVENT is a national multicenter randomized controlled trial in invasively ventilated ICU patients without ARDS with an anticipated duration of ventilation of longer than 24 hours in 5 ICUs in The Netherlands. Consecutive patients are randomly assigned to a low tidal volume strategy using tidal volumes from 4 to 6 ml/kg predicted body weight (PBW) or a high tidal volume ventilation strategy using tidal volumes from 8 to 10 ml/kg PBW. The primary endpoint is the number of ventilator-free days and alive at day 28. Secondary endpoints include ICU and hospital length of stay (LOS), ICU and hospital mortality, the incidence of pulmonary complications, including ARDS, pneumonia, atelectasis, and pneumothorax, the cumulative use and duration of sedatives and neuromuscular blocking agents, incidence of ICU delirium, and the need for decreasing of instrumental dead space. DISCUSSION: PReVENT is the first randomized controlled trial comparing a low tidal volume strategy with a high tidal volume strategy, in patients without ARDS at onset of ventilation, that recruits a sufficient number of patients to test the hypothesis that a low tidal volume strategy benefits patients without ARDS with regard to a clinically relevant endpoint.
trial registrationThe trial is registered at www.clinicaltrials.gov under reference number NCT02153294 on 23 May 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.