ArticlePlacenta2015
The role of chorionic cytotrophoblasts in the smooth chorion fusion with parietal decidua.
Article in Placenta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Heterogeneity in inflammatory responses to endotoxin at the fetomaternal interface.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- A call to standardize the nomenclature of human fetal membrane at the feto-maternal interface.Placenta · 2025Review
- YAP-mediated trophoblast dysfunction: the common pathway underlying pregnancy complications.Cell communication and signaling : CCS · 2023Review
- Regionally distinct trophoblast regulate barrier function and invasion in the human placenta.eLife · 2022Article
- First trimester mechanisms of gestational sac placental and foetal teratogenicity: a framework for birth cohort studies.Human reproduction update · 2021Review
- The Immunology of Syncytialized Trophoblast.International journal of molecular sciences · 2021Review
- Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry.Frontiers in immunology · 2020Article
- The Role of Danger Associated Molecular Patterns in Human Fetal Membrane Weakening.Frontiers in physiology · 2020Review
- Single cell transcriptional signatures of the human placenta in term and preterm parturition.eLife · 2019Article
- Zika Virus Replicates in Proliferating Cells in Explants From First-Trimester Human Placentas, Potential Sites for Dissemination of Infection.The Journal of infectious diseases · 2018Article
- Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo.Current opinion in virology · 2017Review
- Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.Development (Cambridge, England) · 2017Article
- Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition.Human reproduction update · 2016Review
- Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission.Cell host & microbe · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
background/purposeHuman placenta and chorion are rapidly growing transient embryonic organs built from diverse cell populations that are of either, ectodermal [placenta and chorion specific trophoblast (TB) cells], or mesodermal origin [villous core and chorionic mesenchyme]. The development of placenta and chorion is synchronized from the earliest phase of implantation. Little is known about the formative stages of the human chorion, in particular the steps between the formation of a smooth chorion and its fusion with the parietal decidua.
methodsWe examined the available histological material using immunohistochemistry, and further analyzed in vitro the characteristics of the recently established and reported human self-renewing trophoblast progenitor cells (TBPC) derived from chorionic mesoderm.
resultsHere, we provided evidence that the mechanism by which smooth chorion fuses with parietal decidua is the invasion of smooth chorionic cytotrophoblasts (schCTBs) into the uterine wall opposite to the implantation side. This process, which partially replicates some of the mechanisms of the blastocyst implantation, leads to the formation of a new zone of contacts between fetal and maternal cells.
conclusionWe propose the schCTBs invasion of the parietal decidua as a mechanism of 'fusion' of the membranes, and that schCTBs in vivo contribute to the pool of the invasive schCTB.
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