SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016
The comparison between the different generations of autologous chondrocyte implantation with other treatment modalities: a systematic review of clinical trials.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Fabrication and Characterization of Immature Porcine Cartilage-Derived Cell Biomembranes.Journal of functional biomaterials · 2025Article
- [Advances in clinical repair techniques for localized knee cartilage lesions].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- Hydrogel-based autologous chondrocyte implantation leads to subjective improvement levels comparable to scaffold based autologous chondrocyte implantation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Algorithm for Treatment of Focal Cartilage Defects of the Knee: Classic and New Procedures.Cartilage · 2021Review
- Generation and Evaluation of Novel Biomaterials Based on Decellularized Sturgeon Cartilage for Use in Tissue Engineering.Biomedicines · 2021Article
- Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction.BMC musculoskeletal disorders · 2020Article
- Arthroscopic gel-type autologous chondrocyte implantation presents histologic evidence of regenerating hyaline-like cartilage in the knee with articular cartilage defect.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Stem Cell Treatment for Knee Articular Cartilage Defects and Osteoarthritis.Current reviews in musculoskeletal medicine · 2020Review
- Osteochondral Injury, Management and Tissue Engineering Approaches.Frontiers in cell and developmental biology · 2020Review
- Revision Surgery After Cartilage Repair: Data From the German Cartilage Registry (KnorpelRegister DGOU).Orthopaedic journal of sports medicine · 2018Article
- [Cartilage repair of the knee joint].Der Orthopade · 2017Review
- Matrix based autologous chondrocyte implantation in children and adolescents: a match paired analysis in a follow-up over three years post-operation.International orthopaedics · 2017Article
- Applications of Chondrocyte-Based Cartilage Engineering: An Overview.BioMed research international · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis paper aims to review the current evidence for autologous chondrocyte implantation (ACI) generations relative to other treatment modalities, different cell delivery methods and different cell source application.
methodsLiterature search was performed to identify all level I and II studies reporting the clinical and structural outcome of any ACI generation in human knees using the following medical electronic databases: PubMed, EMBASE, Cochrane Library, CINAHL, SPORTDiscus and NICE healthcare database. The level of evidence, sample size calculation and risk of bias were determined for all included studies to enable quality assessment.
resultsTwenty studies were included in the analysis, reporting on a total of 1094 patients. Of the 20 studies, 13 compared ACI with other treatment modalities, seven compared different ACI cell delivery methods, and one compared different cell source for implantation. Studies included were heterogeneous in baseline design, preventing meta-analysis. Data showed a trend towards similar outcomes when comparing ACI generations with other repair techniques and when comparing different cell delivery methods and cell source selection. Majority of the studies (80 %) were level II evidence, and overall the quality of studies can be rated as average to low, with the absence of power analysis in 65 % studies.
conclusionAt present, there are insufficient data to conclude any superiority of ACI techniques. Considering its two-stage operation and cost, it may be appropriate to reserve ACI for patients with larger defects or those who have had inadequate response to other repair procedures until hard evidence enables specific clinical recommendations be made. LEVEL OF EVIDENCE: II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.