SynthesisSports medicine (Auckland, N.Z.)2015
Effects of Oestrogen Treatment on Skeletal Response to Exercise in the Hips and Spine in Postmenopausal Women: A Meta-Analysis.
Synthesis in Sports medicine (Auckland, N.Z.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Impact of menopause hormone therapy, exercise, and their combination on bone mineral density and mental wellbeing in menopausal women: a scoping review.Frontiers in reproductive health · 2025Pooled it
- Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.JAMA network open · 2024Pooled it
- Review
- An Up-Date of the Muscle Strengthening Exercise Effectiveness in Postmenopausal Women with Osteoporosis: A Qualitative Systematic Review.Journal of clinical medicine · 2021Review
- Emerging evidence on the link between depressive symptoms and bone loss in postmenopausal women.International journal of women's health · 2018Review
- Effect of Estrogen on Musculoskeletal Performance and Injury Risk.Frontiers in physiology · 2018Review
- Exercise for the prevention of osteoporosis in postmenopausal women: an evidence-based guide to the optimal prescription.Brazilian journal of physical therapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is recognized that low oestrogen status impairs the skeletal response to mechanical loading in elderly women; therefore, oestrogen administration is expected to increase the osteogenic response to mechanical strain.
objectivesThis meta-analysis aimed to evaluate the combined effects of hormone replacement therapy (HRT) and exercise on femoral neck and lumbar spine bone mineral density (BMD) in postmenopausal women, in comparison with the effects of exercise-only intervention.
methodsA systematic literature search was conducted in PubMed, Embase, SPORTDiscus and ProQuest up to May 1, 2014, to ascertain the influence of oestrogen administration and exercise on BMD in postmenopausal women. The study quality and potential publication bias of the included trials were evaluated. The primary end point was the change in BMD from baseline to follow-up. The effect sizes were estimated in terms of the standardized mean difference (SMD). Subgroup analysis was conducted on the basis of exercise categories.
resultsSix studies with a total of 764 postmenopausal women (aged between 51.8 ± 2.9 and 68.0 ± 3.0 years) met the inclusion criteria. The included studies had low and high levels of heterogeneity of hip outcomes (I2 = 0.0 %) and spine outcomes (I2 = 80.8%), respectively. Fixed- and random-effects models were used for calculating the effect size estimates. The pooled effect sizes associated with the combined interventions of HRT and exercise were significant for femoral neck BMD (SMD 0.220, 95% confidence interval [CI] 0.011-0.429, p = 0.039) and lumbar spine BMD (SMD 0.729, 95% CI 0.186-1.273, p = 0.009) in comparison with the exercise-only intervention. The mixed loading exercise programmes were sensitive to HRT in preventing postmenopausal bone loss in the spine (SMD 1.073, 95% CI 0.140-2.005, p = 0.024) in comparison with single-mode exercise.
conclusionsOur findings indicate that oestrogen treatment significantly increases the skeletal response to exercise training in both the hips and the spine in postmenopausal women, which implies that the combination of oestrogen administration and exercise may generate greater effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.