ArticleJournal of behavioral medicine2015
Perceived ambiguity as a barrier to intentions to learn genome sequencing results.
Article in Journal of behavioral medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Psychological Impact of Ambiguous Health Messages about COVID-19.Journal of behavioral medicine · 2022Trial
- Perceptions of uncertainties about carrier results identified by exome sequencing in a randomized controlled trial.Translational behavioral medicine · 2020Trial
- Integrating genomic medicine into primary care -examining perceptions of community advisory board members.Journal of community genetics · 2026Article
- Ambiguities faced by parents who received a genetic diagnosis for autistic offspring with intellectual disabilities.Journal of community genetics · 2025Article
- Hope, but never expect? Comparing parents' pre- and post-disclosure attitudes toward return of results from diagnostic exome sequencing for their child.Molecular genetics & genomic medicine · 2024Article
- Decisions about adopting novel COVID-19 vaccines among White adults in a rural state, USA: A qualitative study.Health expectations : an international journal of public participation in health care and health policy · 2023Article
- Perceptions and tolerance of uncertainty: relationship to trust in COVID-19 health information and vaccine hesitancy.Journal of behavioral medicine · 2023Article
- Addressing ethical issues related to prenatal diagnostic procedures.Maternal health, neonatology and perinatology · 2023Article
- Navigating the uncertainty: A novel taxonomy of vaccine hesitancy in the context of COVID-19.PloS one · 2023Article
- Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing.British journal of cancer · 2022Article
- Understanding the Patient Experience of Receiving Clinically Actionable Genetic Results from the MyCode Community Health Initiative, a Population-Based Genomic Screening Initiative.Journal of personalized medicine · 2022Article
- 'I Don't Like Uncertainty, I Like to Know': How and why uveal melanoma patients consent to life expectancy prognostication.Health expectations : an international journal of public participation in health care and health policy · 2022Article
- Validation of the multidimensional impact of Cancer Risk Assessment Questionnaire to assess impact of waiting for genome sequencing results.Psycho-oncology · 2022Article
- Article
- Knowing, relationships and trust-citizens' perceptions of whole genome sequencing for the Genetics Clinic of the Future.Journal of community genetics · 2021Article
- Evidence that perceptions of and tolerance for medical ambiguity are distinct constructs: An analysis of nationally representative US data.Health expectations : an international journal of public participation in health care and health policy · 2020Article
- Consent for clinical genome sequencing: considerations from the Clinical Sequencing Exploratory Research Consortium.Personalized medicine · 2019Article
- What do people think about genetics? A systematic review.Journal of community genetics · 2019Review
- How Uncertainty Influences Lay People's Attitudes and Risk Perceptions Concerning Predictive Genetic Testing and Risk Communication.Frontiers in genetics · 2019Article
- Exploring the Issues Surrounding Clinical Exome Sequencing in the Prenatal Setting.Journal of genetic counseling · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Many variants that could be returned from genome sequencing may be perceived as ambiguous-lacking reliability, credibility, or adequacy. Little is known about how perceived ambiguity influences thoughts about sequencing results. Participants (n = 494) in an NIH genome sequencing study completed a baseline survey before sequencing results were available. We examined how perceived ambiguity regarding sequencing results and individual differences in medical ambiguity aversion and tolerance for uncertainty were associated with cognitions and intentions concerning sequencing results. Perceiving sequencing results as more ambiguous was associated with less favorable cognitions about results and lower intentions to learn and share results. Among participants low in tolerance for uncertainty or optimism, greater perceived ambiguity was associated with lower intentions to learn results for non-medically actionable diseases; medical ambiguity aversion did not moderate any associations. Results are consistent with the phenomenon of "ambiguity aversion" and may influence whether people learn and communicate genomic information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.