Evidence map›Paper›PMID 26002934›Full record

ArticleGut2016

Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study.

Amir Zarrinpar, Shakti Gupta, Mano R Maurya, Shankar Subramaniam, Rohit Loomba

Open access · greenAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amir ZarrinparNAFLD Translational Research Unit, University of California, San Diego, La Jolla, California, USA Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Shakti GuptaDepartment of Bioengineering, San Diego Supercomputer Center, University of California, San Diego, La Jolla, California, USA.
Mano R MauryaDepartment of Bioengineering, San Diego Supercomputer Center, University of California, San Diego, La Jolla, California, USA.
Shankar SubramaniamDepartment of Bioengineering, San Diego Supercomputer Center, University of California, San Diego, La Jolla, California, USA Departments of Computer Science & Engineering and Cellular & Molecular Medicine, University of California, San Diego, La Jolla, California, USA.
Rohit LoombaNAFLD Translational Research Unit, University of California, San Diego, La Jolla, California, USA Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA Division of Epidemiology, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, USA.
University of California, San Diego · USSan Diego Supercomputer Center · US

Funding

Systems Biology Analyses for Hemodynamic Regulation of Vascular HomeostasisR01HL108735 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, SHYY, JOHN YJ · 2012 to 2024
$13.4M
Shear Regulation of MicroRNA Transportomes and Targetomes in Vascular HomeostasisR01HL106579 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, SHYY, JOHN YJ · 2011 to 2022
$8.3M
Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
San Diego Clinical and Translational Research InstituteKL2TR000099 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$1.1M
The Relationship of Gut Microbiome and Time Restricted Feeding in MetabolismK08DK102902 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZARRINPAR, AMIR · 2015 to 2019
$789k
GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASEK23DK090303 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2011 to 2014
$721k
NCATS NIH HHS KL2 TR000099NHLBI NIH HHS R01 HL106579NHLBI NIH HHS R01 HL108735NIDDK NIH HHS K08 DK102902NIDDK NIH HHS K23 DK090303NIDDK NIH HHS T32 DK007202
6 · The paper itself

Abstract

objectiveIn the setting where two individuals are genetically similar, epigenetic mechanisms could account for discordance in the presence or absence of non-alcoholic fatty liver disease (NAFLD). This study investigated if serum microRNAs (miRs) could explain discordance in NAFLD.

designThis is a cross-sectional analysis of a prospective cohort study of 40 (n=80) twin-pairs residing in Southern California. All participants underwent a standardised research visit, liver MRI using proton-density fat fraction to quantify fat content and miR profiling of their serum.

resultsAmong the 40 twin-pairs, there were 6 concordant for NAFLD, 28 were concordant for non-NAFLD and 6 were discordant for NAFLD. The prevalence of NAFLD was 22.5% (18/80). Within the six discordant twins, a panel of 10 miRs differentiated the twin with NAFLD from the one without. Two of these miRs, miR-331-3p and miR-30c, were also among the 21 miRs that were different between NAFLD and non-NAFLD groups (for miR-331-3p: 7.644±0.091 vs 8.057±0.071, respectively, p=0.004; for miR-30c: 10.013±0.126 vs 10.418±0.086, respectively, p=0.008). Both miRs were highly heritable (35.9% and 10.7%, respectively) and highly correlated with each other (R=0.90, p=2.2×10(-16)) suggesting involvement in a common mechanistic pathway. An interactome analysis of these two miRs showed seven common target genes.

conclusionsUsing a novel human twin-study design, we demonstrate that discordancy in liver fat content between the twins can be explained by miRs, and that they are heritable.

Indexed as

MicroRNAsNon-alcoholic Fatty Liver DiseaseCaliforniaCross-Sectional StudiesEpigenesis, GeneticFemaleGene Expression ProfilingHumansLiverMagnetic Resonance ImagingMaleMiddle AgedPrevalenceProspective StudiesTwins, DizygoticTwins, MonozygoticMicroRNAsMIRN30b microRNA, humanMIRN331 microRNA, humanFATTY LIVERGENETICSLIVERNONALCOHOLIC STEATOHEPATITISOBESITY

Identifiers

PMID26002934
PMCPMC5089367
OpenAlexW1943556640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.