Evidence map›Paper›PMID 26002909›Full record

ArticlePlant physiology2015

GENERAL CONTROL NONREPRESSED PROTEIN5-Mediated Histone Acetylation of FERRIC REDUCTASE DEFECTIVE3 Contributes to Iron Homeostasis in Arabidopsis.

Jiewen Xing, Tianya Wang, Zhenshan Liu, Jianqin Xu, Yingyin Yao, Zhaorong Hu, Huiru Peng, Mingming Xin, Futong Yu, Daoxiu Zhou and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 63 citations in OpenAlex.

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  14. Review
  15. Epigenetic Mechanisms of Plant Adaptation to Biotic and Abiotic Stresses.International journal of molecular sciences · 2020
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jiewen XingState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).ORCID http://orcid.org/0000-0003-3503-0739
Tianya WangState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).
Zhenshan LiuState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).
Jianqin XuState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).
Yingyin YaoState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).
Zhaorong HuState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).ORCID http://orcid.org/0000-0002-1815-648X
Huiru PengState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).
Mingming XinState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).
Futong YuState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).ORCID http://orcid.org/0000-0001-8672-3610
Daoxiu ZhouState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.).ORCID http://orcid.org/0000-0002-1540-0598
Zhongfu NiState Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.), and College of Resources and Environmental Sciences (J.Xu, F.Y.), China Agricultural University, Beijing 100193, China;National Plant Gene Research Centre, Beijing 100193, China (J.Xi., T.W., Z.L., Y.Y., Z.H., H.P., M.X., Z.N.); andInstitut de Biologie des Plantes, Unité Mixte de Recherche 8618, Université Paris Sud, 91405 Orsay, France (D.Z.) nizf@cau.edu.cn.
Université Paris-Sud · FRState Key Laboratory of Plant Genomics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron homeostasis is essential for plant growth and development. Here, we report that a mutation in GENERAL CONTROL NONREPRESSED PROTEIN5 (GCN5) impaired iron translocation from the root to the shoot in Arabidopsis (Arabidopsis thaliana). Illumina high-throughput sequencing revealed 879 GCN5-regulated candidate genes potentially involved in iron homeostasis. Chromatin immunoprecipitation assays indicated that five genes (At3G08040, At2G01530, At2G39380, At2G47160, and At4G05200) are direct targets of GCN5 in iron homeostasis regulation. Notably, GCN5-mediated acetylation of histone 3 lysine 9 and histone 3 lysine 14 of FERRIC REDUCTASE DEFECTIVE3 (FRD3) determined the dynamic expression of FRD3. Consistent with the function of FRD3 as a citrate efflux protein, the iron retention defect in gcn5 was rescued and fertility was partly restored by overexpressing FRD3. Moreover, iron retention in gcn5 roots was significantly reduced by the exogenous application of citrate. Collectively, these data suggest that GCN5 plays a critical role in FRD3-mediated iron homeostasis. Our results provide novel insight into the chromatin-based regulation of iron homeostasis in Arabidopsis.

Indexed as

Gene Expression Regulation, PlantAcetylationArabidopsisArabidopsis ProteinsBase SequenceHigh-Throughput Nucleotide SequencingHistone AcetyltransferasesHistonesHomeostasisIronMembrane Transport ProteinsMolecular Sequence DataMutationp300-CBP-Associated FactorPhenotypePlant RootsArabidopsis ProteinsFRD3 protein, ArabidopsisGCN5 protein, ArabidopsisHistone AcetyltransferasesHistonesIronMembrane Transport Proteinsp300-CBP-Associated Factor

Identifiers

PMID26002909
PMCPMC4528745
OpenAlexW1824920939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.