ArticleEukaryotic cell2015
Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis.
Article in Eukaryotic cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Genomic Analysis Reveals Diversified and Stress-Responsive Transport Repertoire inJournal of fungi (Basel, Switzerland) · 2026Article
- A highly conserved tRNA modification contributes toMicrobiology spectrum · 2024Article
- Nutritional immunity: targeting fungal zinc homeostasis.Heliyon · 2021Review
- Transcriptional response of Candida albicans to Pseudomonas aeruginosa in a polymicrobial biofilm.G3 (Bethesda, Md.) · 2021Article
- The F-Box Protein Fbp1 Regulates Virulence ofFrontiers in cellular and infection microbiology · 2021Article
- Zinc at the Host-Fungus Interface: How to Uptake the Metal?Journal of fungi (Basel, Switzerland) · 2020Review
- Zinc homeostasis in the secretory pathway in yeast.Current opinion in chemical biology · 2020Review
- ZafA-mediated regulation of zinc homeostasis is required for virulence in the plant pathogen Fusarium oxysporum.Molecular plant pathology · 2020Article
- Transcription factors and transporters in zinc homeostasis: lessons learned from fungi.Critical reviews in biochemistry and molecular biology · 2020Review
- Insights IntoFrontiers in cellular and infection microbiology · 2020Article
- Zinc and Iron Homeostasis: Target-Based Drug Screening as New Route for Antifungal Drug Development.Frontiers in cellular and infection microbiology · 2019Article
- The Transcription Factor ZafA Regulates the Homeostatic and Adaptive Response to Zinc Starvation inGenes · 2018Article
- Biphasic zinc compartmentalisation in a human fungal pathogen.PLoS pathogens · 2018Article
- Metals in fungal virulence.FEMS microbiology reviews · 2018Review
- Transcriptome sequencing and analysis of zinc-uptake-related genes in Trichophyton mentagrophytes.BMC genomics · 2017Article
- Bridging the Gap to Non-toxic Fungal Control: Lupinus-Derived Blad-Containing Oligomer as a Novel Candidate to Combat Human Pathogenic Fungi.Frontiers in microbiology · 2017Article
- The biological inorganic chemistry of zinc ions.Archives of biochemistry and biophysics · 2016Article
- Zinc sensing and regulation in yeast model systems.Archives of biochemistry and biophysics · 2016Review
- The roles of zinc and copper sensing in fungal pathogenesis.Current opinion in microbiology · 2016Review
- The Zinc Transport Systems and Their Regulation in Pathogenic Fungi.Mycobiology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The supply and intracellular homeostasis of trace metals are essential for every living organism. Therefore, the struggle for micronutrients between a pathogen and its host is an important determinant in the infection process. In this work, we focus on the acquisition of zinc by Candida dubliniensis, an emerging pathogen closely related to Candida albicans. We show that the transcription factor Csr1 is essential for C. dubliniensis to regulate zinc uptake mechanisms under zinc limitation: it governs the expression of the zinc transporter genes ZRT1, ZRT2, and ZRT3 and of the zincophore gene PRA1. Exclusively, artificial overexpression of ZRT2 partially rescued the growth defect of a csr1Δ/Δ mutant in a zinc-restricted environment. Importantly, we found that, in contrast to what is seen in C. albicans, Csr1 (also called Zap1) is not a major regulator of dimorphism in C. dubliniensis. However, although a csr1Δ/Δ strain showed normal germ tube formation, we detected a clear attenuation in virulence using an embryonated chicken egg infection model. We conclude that, unlike in C. albicans, Csr1 seems to be a virulence factor of C. dubliniensis that is not coupled to filamentation but is strongly linked to zinc acquisition during pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.