Evidence map›Paper›PMID 26002590›Full record

Trial reportActa diabetologica2016

Effect of vitamin E supplementation on HDL function by haptoglobin genotype in type 1 diabetes: results from the HapE randomized crossover pilot trial.

Tina Costacou, Andrew P Levy, Rachel G Miller, Janet Snell-Bergeon, Rabea Asleh, Dan Farbstein, Catherine E Fickley, Georgia Pambianco, Rona de la Vega, Rhobert W Evans and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta diabetologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Tina CostacouDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA. costacout@edc.pitt.edu.
Andrew P LevyDepartment of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Rachel G MillerDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Janet Snell-BergeonBarbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO, USA.
Rabea AslehDepartment of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Dan FarbsteinDepartment of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Catherine E FickleyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Georgia PambiancoDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Rona de la VegaDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Rhobert W EvansDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Trevor J OrchardDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
University of Pittsburgh · USTechnion – Israel Institute of Technology · ILUniversity of Colorado Denver · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Complications and Comorbidities of Type 1 DiabetesR01HL113029 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SNELL-BERGEON, JANET KATHLEEN · 2013 to 2016
$2.9M
NCATS NIH HHS UL1 TR000005NHLBI NIH HHS R01 HL113029
6 · The paper itself

Abstract

aimsHaptoglobin (Hp) genotype 2-2 increases cardiovascular diabetes complications. In type 2 diabetes, α-tocopherol was shown to lower cardiovascular risk in Hp 2-2, potentially through HDL function improvements. Similar type 1 diabetes data are lacking. We conducted a randomized crossover pilot of α-tocopherol supplementation on HDL function [i.e., cholesterol efflux (CE) and HDL-associated lipid peroxides (LP)] and lipoprotein subfractions in type 1 diabetes.

methodsHp genotype was assessed in members of two Allegheny County, PA, type 1 diabetes registries and the CACTI cohort; 30 were randomly selected within Hp genotype, and 28 Hp 1-1, 31 Hp 2-1 and 30 Hp 2-2 were allocated to daily α-tocopherol or placebo for 8 weeks with a 4-week washout.

resultsBaseline CE decreased with the number of Hp 2 alleles (p-trend = 0.003). There were no differences in LP or lipoprotein subfractions. In intention-to-treat analysis stratified by Hp, α-tocopherol increased CE in Hp 2-2 (β = 0.79, p = 0.03) and LP in Hp 1 allele carriers (β Hp 1-1 = 0.18, p = 0.05; β Hp 2-1 = 0.21, p = 0.07); reduced HDL particle size (β = -0.07, p = 0.03) in Hp 1-1 carriers; increased LDL particle concentration in Hp 1-1; and decreased it in Hp 2-2 carriers. However, no significant interactions were observed by Hp.

conclusionsIn this type 1 diabetes study, HDL function worsened with the number of Hp 2 alleles. α-Tocopherol improved HDL function in Hp 2-2 carriers and appeared to adversely affect lipid peroxides and lipoprotein subfractions among Hp 1 allele carriers. As no significant interactions were observed, findings require replication in larger studies.

Indexed as

AdultAgedAllelesCohort StudiesCross-Over StudiesDiabetes Mellitus, Type 1Dietary SupplementsDouble-Blind MethodFemaleGenotypeHaptoglobinsHumansLipid PeroxidationLipoproteins, HDLLipoproteins, LDLMaleHaptoglobinsLipoproteins, HDLLipoproteins, LDLVitamin EVitaminsDouble-blinded placebo-controlled randomized trialHaptoglobin genotypeHDL functionNMR lipoprotein subfractionsType 1 diabetesVitamin E

Identifiers

PMID26002590
PMCPMC4826317
OpenAlexW253979462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.