ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2016
Depression is associated with increased incidence of osteoporotic thoracolumbar fracture in postmenopausal women: a prospective study.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 30 citations in OpenAlex.
- Mechano responsiveness of neuroimmune cross-talk in bone and joints: A narrative review with implications for force-based manipulations.Musculoskeletal science & practice · 2026Review
- Psychosomatic interplay in postmenopausal osteoporosis: from neuroendocrine mechanisms to structured psychological therapies and long-term management.Frontiers in psychiatry · 2026Review
- Variation in thoracic inlet measurements and its correlation with pulmonary dysfunction in kyphoscoliotic deformities: a prospective case-control study.Spine deformity · 2024Article
- Effects of Psychogenic Stress Frequency during the Growth Stage on Oxidative Stress, Organ and Bone Development.Journal of bone metabolism · 2024Article
- [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Fracture healing research: Recent insights.Bone reports · 2023Review
- Red flags to screen for vertebral fracture in people presenting with low back pain.The Cochrane database of systematic reviews · 2023Review
- Neutrophil-derived catecholamines mediate negative stress effects on bone.Nature communications · 2023Article
- Article
- Prevalence and risk factors for depressive and anxiety symptoms in middle-aged Chinese women: a community-based cross-sectional study.BMC women's health · 2022Article
- The psychobiological links between chronic stress-related diseases, periodontal/peri-implant diseases, and wound healing.Periodontology 2000 · 2021Review
- Depression, falls, and osteoporotic fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Modified percutaneous Kyphoplasty technique in the treatment of osteoporotic thoracolumbar burst fractures: could it reduce the odds of cement leakage?BMC surgery · 2020Article
- Article
- Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Role of the Intestinal Microbiome in Chronic Psychosocial Stress-Induced Pathologies in Male Mice.Frontiers in behavioral neuroscience · 2018Article
- Chronic psychosocial stress disturbs long-bone growth in adolescent mice.Disease models & mechanisms · 2017Article
- Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study.Clinics (Sao Paulo, Brazil) · 2017Article
- The Relationship between Locomotive Syndrome and Depression in Community-Dwelling Elderly People.Current gerontology and geriatrics research · 2017Article
- Osteoporotic Patients with Thoracolumbar Scoliosis Are at Higher Risk for Developing Thoracolumbar Spinal Fractures: A 7,000 Patient Population Cross-Sectional Study.JB & JS open accessArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
proposeTo determine whether depression in postmenopausal women with osteoporosis is associated with an increased risk of thoracolumbar fragility fracture.
methodsPostmenopausal women with osteoporosis and without prior vertebral fracture history who were seen at our institution from January 2006 to January 2010 (n = 1397) were divided into depression group (n = 494) and depression-free group (n = 903). After at least 4 years the incidence of thoracolumbar osteoporotic vertebral fracture was compared between the groups. For those who developed vertebral fracture, quality of life over the subsequent 2 months and fracture pain in the subsequent 2 weeks were compared. Depression was assessed with the 21-item Beck Depression Inventory, pain intensity with the visual analogue scale and quality of life with the Medical Outcomes Study 36-item Short-Form Survey.
resultsThe incidence of thoracolumbar fractures among women with continuous depression was higher than the group without depression (35.43 vs. 25.14 %, respectively; (P < 0.05). Osteoporotic thoracolumbar fractures were associated with significantly lower quality of life scores in women with depression than in those without depression (P < 0.05). Fracture pain was experienced by a higher percentage of patients with continuous depression than by those without depression (44.00 vs. 27.31 %; P < 0.05).
conclusionDepression is associated with a higher risk of thoracolumbar fracture, with more fracture pain and with lower quality of life in the 2 months following fracture.
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