Evidence map›Paper›PMID 26002350›Full record

ArticleImplementation science : IS2015

The feasibility of implementing recovery, psychosocial and pharmacological interventions for psychosis: comparison study.

Lian van der Krieke, Victoria Bird, Mary Leamy, Faye Bacon, Rebecca Dunn, Francesca Pesola, Monika Janosik, Clair Le Boutillier, Julie Williams, Mike Slade

Open access · goldAbstract readComparative Study
In one paragraph

Article in Implementation science : IS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lian van der KriekeUniversity Medical Center Groningen, University Center for Psychiatry, University of Groningen, Groningen, The Netherlands. j.a.j.van.der.krieke@umcg.nl.
Victoria BirdHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. victoria.bird@kcl.ac.uk.
Mary LeamyHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. mary.leamy@kcl.ac.uk.
Faye BaconHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. faye.bacon@kcl.ac.uk.
Rebecca DunnHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. rebecca.dunn@kcl.ac.uk.
Francesca PesolaHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. francesca.pesola@kcl.ac.uk.
Monika JanosikHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. monika.janosik@kcl.ac.uk.
Clair Le BoutillierHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. clair.le_boutillier@kcl.ac.uk.
Julie WilliamsHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. julie.williams@kcl.ac.uk.
Mike SladeHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. mike.slade@kcl.ac.uk.
King's College London · GBUniversity of Groningen · NL

Funding

Department of Health RP-PG-0707-10040
6 · The paper itself

Abstract

backgroundClinical guidelines for the treatment of people experiencing psychosis have existed for over a decade, but implementation of recommended interventions is limited. Identifying influences on implementation may help to reduce this translational gap. The Structured Assessment of Feasibility (SAFE) measure is a standardised assessment of implementation blocks and enablers. The aim of this study was to characterise and compare the implementation blocks and enablers for recommended psychosis interventions.

methodsSAFE was used to evaluate and compare three groups of interventions recommended in the 2014 NICE psychosis guideline: pharmacological (43 trials testing 5 interventions), psychosocial (65 trials testing 5 interventions), and recovery (19 trials testing 5 interventions). The 127 trial reports rated with SAFE were supplemented by published intervention manuals, research protocols, trial registrations and design papers. Differences in the number of blocks and enablers across the three interventions were tested statistically, and feasibility profiles were generated.

resultsThere was no difference between psychosocial and recovery interventions in the number of blocks or enablers to implementation. Pharmacological interventions (a) had fewer blocks than both psychosocial interventions (χ (2)(3) = 133.77, p < 0.001) and recovery interventions (χ (2)(3) = 104.67, p < 0.001) and (b) did not differ in number of enablers from recovery interventions (χ (2)(3) = 0.74, p = 0.863) but had fewer enablers than psychosocial interventions (χ (2)(3) = 28.92, p < 0.001). Potential adverse events associated with the intervention tend to be a block for pharmacological interventions, whereas complexity of the intervention was the most consistent block for recovery and psychosocial interventions.

conclusionsFeasibility profiles show that pharmacological interventions are relatively easy to implement but can sometimes involve risks. Psychosocial and recovery interventions are relatively complex but tend to be more flexible and more often manualised. SAFE ratings can contribute to tackling the current implementation challenges in mental health services, by providing a reporting guideline structure for researchers to maximise the potential for implementation and by informing prioritisation decisions by clinical guideline developers and service managers.

Indexed as

Practice Guidelines as TopicAntipsychotic AgentsHumansPsychotherapyPsychotic DisordersState MedicineUnited KingdomAntipsychotic Agents

Identifiers

PMID26002350
PMCPMC4453226
OpenAlexW1587546753

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.