ArticleIntegrative and comparative biology2015
Molecular Evidence for Convergence and Parallelism in Evolution of Complex Brains of Cephalopod Molluscs: Insights from Visual Systems.
Article in Integrative and comparative biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 63 citations in OpenAlex.
- Protocol for genotyping cephalopod sex using a skin swab and quantitative PCR.STAR protocols · 2026Article
- Protocol for genotyping cephalopod sex using a skin swab and quantitative PCR.bioRxiv : the preprint server for biology · 2026Article
- An Ocean of Opsins.Genome biology and evolution · 2025Article
- Expression of proteins supporting visual function in heterobranch gastropods.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- A possible origin of the inverted vertebrate retina revealed by physical modeling.Journal of biological physics · 2024Article
- Embryonic development of a centralised brain in coleoid cephalopods.Neural development · 2024Review
- Molluscan Genomes Reveal Extensive Differences in Photopigment Evolution Across the Phylum.Molecular biology and evolution · 2023Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
- Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts.Science China. Life sciences · 2023Article
- Duplication and Losses of Opsin Genes in Lophotrochozoan Evolution.Molecular biology and evolution · 2023Article
- Neurotransmission and neuromodulation systems in the learning and memory network of Octopus vulgaris.Journal of morphology · 2022Article
- The Genome of the Marine Rotifer Brachionus manjavacas: Genome-Wide Identification of 310 G Protein-Coupled Receptor (GPCR) Genes.Marine biotechnology (New York, N.Y.) · 2022Article
- Diffusion MRI Connections in the Octopus Brain.Experimental neurobiology · 2022Article
- The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes.BMC ecology and evolution · 2021Article
- An evolutionary process without variation and selection.Journal of the Royal Society, Interface · 2021Article
- The genome of Nautilus pompilius illuminates eye evolution and biomineralization.Nature ecology & evolution · 2021Article
- Krüppel-like factor/specificity protein evolution in the Spiralia and the implications for cephalopod visual system novelties.Proceedings. Biological sciences · 2020Article
- Evolution and development of complex eyes: a celebration of diversity.Development (Cambridge, England) · 2020Review
- The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution.eLife · 2020Article
- Sensorial Hierarchy inAnimals : an open access journal from MDPI · 2020Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Coleoid cephalopods show remarkable evolutionary convergence with vertebrates in their neural organization, including (1) eyes and visual system with optic lobes, (2) specialized parts of the brain controlling learning and memory, such as vertical lobes, and (3) unique vasculature supporting such complexity of the central nervous system. We performed deep sequencing of eye transcriptomes of pygmy squids (Idiosepius paradoxus) and chambered nautiluses (Nautilus pompilius) to decipher the molecular basis of convergent evolution in cephalopods. RNA-seq was complemented by in situ hybridization to localize the expression of selected genes. We found three types of genomic innovations in the evolution of complex brains: (1) recruitment of novel genes into morphogenetic pathways, (2) recombination of various coding and regulatory regions of different genes, often called "evolutionary tinkering" or "co-option", and (3) duplication and divergence of genes. Massive recruitment of novel genes occurred in the evolution of the "camera" eye from nautilus' "pinhole" eye. We also showed that the type-2 co-option of transcription factors played important roles in the evolution of the lens and visual neurons. In summary, the cephalopod convergent morphological evolution of the camera eyes was driven by a mosaic of all types of gene recruitments. In addition, our analysis revealed unexpected variations of squids' opsins, retinochromes, and arrestins, providing more detailed information, valuable for further research on intra-ocular and extra-ocular photoreception of the cephalopods.
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