Evidence map›Paper›PMID 26002057›Full record

ArticleClinical biomechanics (Bristol, Avon)2015

An approach for determining quantitative measures for bone volume and bone mass in the pediatric spina bifida population.

Rachel E Horenstein, Sandra J Shefelbine, Nicole M Mueske, Carissa L Fisher, Tishya A L Wren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Predictors of Walking Activity in Children and Adolescents With Myelomeningocele.Archives of physical medicine and rehabilitation · 2020
    Article
  6. Article
  7. Article
  8. Advanced skeletal maturity in children and adolescents with myelomeningocele.Journal of pediatric rehabilitation medicine · 2017
    Article
  9. Muscle-Bone Interactions in Pediatric Bone Diseases.Current osteoporosis reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Rachel E HorensteinDepartment of Biomedical Engineering, University of Southern California, Los Angeles CA, United States. Electronic address: horenstein.r@husky.neu.edu.
Sandra J ShefelbineDepartment of Mechanical and Industrial Engineering, Northeastern University, Boston MA, United States.
Nicole M MueskeChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles CA, United States.
Carissa L FisherChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles CA, United States.
Tishya A L WrenDepartment of Biomedical Engineering, University of Southern California, Los Angeles CA, United States; Children's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles CA, United States.
University of Southern California · USChildren's Hospital of Los Angeles · USNortheastern University · USOrthopaedic Center · US

Funding

Risk Factors for Osteoporosis in Children & Adolescents with MyelomeningoceleR01HD059826 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WREN, TISHYA A L · 2010 to 2014
$2.4M
NICHD NIH HHS 5R01HD059826NICHD NIH HHS R01 HD059826
6 · The paper itself

Abstract

backgroundThe pediatric spina bifida population suffers from decreased mobility and recurrent fractures. This study aimed to develop a method for quantifying bone mass along the entire tibia in youth with spina bifida. This will provide information about all potential sites of bone deficiencies.

methodsComputed tomography images of the tibia for 257 children (n=80 ambulatory spina bifida, n=10 non-ambulatory spina bifida, n=167 typically developing) were analyzed. Bone area was calculated at regular intervals along the entire tibia length and then weighted by calibrated pixel intensity for density weighted bone area. Integrals of density weighted bone area were used to quantify bone mass in the proximal and distal epiphyses and diaphysis. Group differences were evaluated using analysis of variance.

findingsNon-ambulatory children suffer from decreased bone mass in the diaphysis and proximal and distal epiphyses compared to ambulatory and control children (P≤0.001). Ambulatory children with spina bifida showed statistically insignificant differences in bone mass in comparison to typically developing children at these sites (P>0.5).

interpretationThis method provides insight into tibial bone mass distribution in the pediatric spina bifida population by incorporating information along the whole length of the bone, thereby providing more information than dual-energy x-ray absorptiometry and peripheral quantitative computed tomography. This method can be applied to any population to assess bone mass distribution across the length of any long bone.

Indexed as

Absorptiometry, PhotonAdolescentAnalysis of VarianceBone DensityCase-Control StudiesChildFemaleHumansMaleSpinal DysraphismTibiaTomography, X-Ray ComputedBone densityBone massImage analysisMyelomeningoceleSpina bifida

Identifiers

PMID26002057
PMCPMC4523422
OpenAlexW2126905997

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.