ArticleJournal of computational neuroscience2015
Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment.
Article in Journal of computational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- The impact of dynamic reversal potential on the evolution of action potential attributes during spike trains.Frontiers in computational neuroscience · 2025Article
- Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- New methods for quantifying rapidity of action potential onset differentiate neuron types.PloS one · 2021Article
- The location of the axon initial segment affects the bandwidth of spike initiation dynamics.PLoS computational biology · 2020Article
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Authors and funding
3 authors.
Funding
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Abstract
Somatic action potentials (AP) of cortical pyramidal neurons have characteristically high onset-rapidness. The onset of the AP waveform is an indirect measure for the ability of a neuron to respond to temporally fast-changing stimuli. Theoretical studies on the pyramidal neuron response usually involves a canonical Hodgkin-Huxley (HH) type ion channel gating model, which assumes statistically independent gating of each individual channel. However, cooperative activity of ion channels are observed for various cell types, meaning that the activity (e.g. opening) of one channel triggers the activity (e.g. opening) of a certain fraction of its neighbors and hence, these groups of channels behave as a unit. In this study, we describe a multi-compartmental conductance-based model with cooperatively gating voltage-gated Na channels in the axon initial segment. Our model successfully reproduced the somatic sharp AP onsets of cortical pyramidal neurons. The onset latencies from the initiation site to the soma and the conduction velocities were also in agreement with the previous experimental studies.
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Registered trials
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