ArticlePloS one2015
Molecular Epidemiology of Clostridium difficile Infection in a Large Teaching Hospital in Thailand.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antimicrobial resistance in Clostridioides (Clostridium) difficile derived from humans: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2020Pooled it
- Molecular epidemiology ofMicrobiology spectrum · 2026Article
- Update on Commonly Used Molecular Typing Methods forMicroorganisms · 2023Review
- Article
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- Molecular epidemiology ofAntimicrobial resistance and infection control · 2019Article
- Review
- High Prevalence of Toxigenic and Nontoxigenic Clostridium difficile Strains in Malaysia.Journal of clinical microbiology · 2018Article
- A multi-institutional cohort study confirming the risks of Clostridium difficile infection associated with prolonged antibiotic prophylaxis.The Journal of thoracic and cardiovascular surgery · 2018Article
- Clostridium difficile infection in the Lao People's Democratic Republic: first isolation and review of the literature.BMC infectious diseases · 2017Review
- Frequency of antibiotic associated diarrhea caused byGastroenterology and hepatology from bed to bench · 2017Article
- Toxin A-negative toxin B-positive ribotype 017 Clostridium difficile is the dominant strain type in patients with diarrhoea attending tuberculosis hospitals in Cape Town, South Africa.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Prevalence and molecular epidemiology ofNew microbes and new infections · 2017Article
- Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolates from two Korean hospitals.PloS one · 2017Article
- Antimicrobial susceptibility ofAntimicrobial resistance and infection control · 2017Article
- Characterisation of Clostridium difficile strains isolated from Groote Schuur Hospital, Cape Town, South Africa.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Correction: Molecular Epidemiology of Clostridium difficile Infection in a Large Teaching Hospital in Thailand.PloS one · 2015Article
- Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
- Erratum issuedCorrection: Molecular Epidemiology of Clostridium difficile Infection in a Large Teaching Hospital in Thailand.2015 · Pusathit, Papanin [corrected to Putsathit, Papanin]
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium difficile infection (CDI) is a leading cause of healthcare-associated morbidity and mortality worldwide. In Thailand, CDI exhibits low recurrence and mortality and its molecular epidemiology is unknown. CDI surveillance was conducted in a tertiary facility (Siriraj Hospital, Bangkok). A total of 53 toxigenic C. difficile strains from Thai patients were analyzed by multi-locus sequence typing (MLST), PCR ribotyping, and pulse-field gel electrophoresis (PFGE). The mean age of the cohort was 64 years and 62.3% were female; 37.7% of patients were exposed to > two antibiotics prior to a diagnosis of CDI, with beta-lactams the most commonly used drug (56.3%). Metronidazole was used most commonly (77.5%; success rate 83.9%), and non-responders were treated with vancomycin (success rate 100%). None of the isolates carried binary toxin genes. Most isolates (98.2-100%) were susceptible to metronidazole, vancomycin, tigecycline and daptomycin. There were 11 sequence types (STs), 13 ribotypes (RTs) and four PFGE types. Six previously identified STs (ST12, ST13, ST14, ST33, ST41 and ST45) and five novel STs unique to Thailand (ST66, ST67, ST68, ST69 and ST70) were identified. PCR RTs UK 017 (ST45) (45.3%) and UK 014/020 (ST33) (24.5%) were the most common. High concordance was observed between the MLST and ribotyping results (p<0.001). C. difficile isolates from Thai patients were highly susceptible to standard antimicrobial agents. In conclusion, the five STs indicate the high genetic diversity and unique polymorphisms in Thailand. Moreover, the emergence of antimicrobial resistance to vancomycin warranted continuous surveillance to prevent further spread of the toxigenic C. difficile isolates.
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