Evidence map›Paper›PMID 26000748›Full record

ArticleChemistry & biology2015

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons.

Emmanuel Y Dotsey, Kwang-Mook Jung, Abdul Basit, Don Wei, Jennifer Daglian, Federica Vacondio, Andrea Armirotti, Marco Mor, Daniele Piomelli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

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  15. Monoglyceride lipase: Structure and inhibitors.Chemistry and physics of lipids · 2016
    Review
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  18. The Expanding Landscape of the Thiol Redox Proteome.Molecular & cellular proteomics : MCP · 2016
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Emmanuel Y DotseyDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA.
Kwang-Mook JungDepartment of Anatomy and Neurobiology, University of California, 3101 Gillespie NRF, Irvine, CA 92697-1275, USA.
Abdul BasitDrug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.
Don WeiDepartment of Anatomy and Neurobiology, University of California, 3101 Gillespie NRF, Irvine, CA 92697-1275, USA.
Jennifer DaglianDepartment of Anatomy and Neurobiology, University of California, 3101 Gillespie NRF, Irvine, CA 92697-1275, USA.
Federica VacondioDipartimento Farmaceutico, University of Parma, Parma 43100, Italy.
Andrea ArmirottiDrug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.
Marco MorDipartimento Farmaceutico, University of Parma, Parma 43100, Italy.
Daniele PiomelliDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA; Department of Anatomy and Neurobiology, University of California, 3101 Gillespie NRF, Irvine, CA 92697-1275, USA; Drug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genoa, Italy; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: piomelli@uci.edu.
University of California, Irvine · USItalian Institute of Technology · ITUniversity of Parma · IT

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Characterization of Anandamide Transport in BrainR01DA012413 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI PIOMELLI, DANIELE · 1998 to 2016
$4.7M
Optimization and preclinical development of FAAH inhibitors for smoking cessationDP1DA031387 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI PIOMELLI, DANIELE · 2010 to 2014
$3.7M
NIDA NIH HHS DA012413NIDA NIH HHS DA031387NIDA NIH HHS DP1 DA031387NIDA NIH HHS R01 DA012413NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

The second messenger hydrogen peroxide transduces changes in the cellular redox state by reversibly oxidizing protein cysteine residues to sulfenic acid. This signaling event regulates many cellular processes but has never been shown to occur in the brain. Here, we report that hydrogen peroxide heightens endocannabinoid signaling in brain neurons through sulfenylation of cysteines C201 and C208 in monoacylglycerol lipase (MGL), a serine hydrolase that deactivates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG) in nerve terminals. The results suggest that MGL sulfenylation may provide a presynaptic control point for 2-AG-mediated endocannabinoid signaling.

Indexed as

Amino Acid SequenceAnimalsArachidonic AcidsBrainCells, CulturedCysteineEndocannabinoidsFemaleGlyceridesHeLa CellsHumansHydrogen PeroxideKineticsMonoacylglycerol LipasesMutagenesis, Site-DirectedNeuronsArachidonic AcidsCysteineEndocannabinoidsGlyceridesglyceryl 2-arachidonateHydrogen PeroxideMonoacylglycerol LipasesReceptor, Cannabinoid, CB1Recombinant ProteinsSulfenic Acids

Identifiers

PMID26000748
PMCPMC4459529
OpenAlexW1517757665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.