ArticlePloS one2015
Cancer Incidence among Patients with Anorexia Nervosa from Sweden, Denmark and Finland.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Parental mental illness and the risk of offspring cancer in childhood: a pooled meta-analysis of English and Swedish national cohorts.BMC psychiatry · 2025Pooled it
- Relationship between irregular diet and risk of esophageal cancer: A meta-analysis.Frontiers in genetics · 2022Pooled it
- Eating disorders and the risk of developing cancer: a systematic review.Eating and weight disorders : EWD · 2021Pooled it
- Association of Anorexia Nervosa With Risk of Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Network analysis of the genetic relationships between twenty psychiatric and substance use disorders.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- The typology of common psychiatric disorders as depicted by genetic maps: a study based on Swedish population-based registers.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Eating Disorders and Later Incidence of Cancer: A Nationwide Longitudinal Study in Denmark.Biological psychiatry global open science · 2025Article
- The moderation of genetic risk for ten major psychiatric and substance use disorders by the genetic aptitude for educational attainment.Molecular psychiatry · 2025Article
- Excessive vitamin BJournal of eating disorders · 2025Article
- Low risk of some common cancers in women with anorexia nervosa: Evidence from a national record-linkage study.Acta psychiatrica Scandinavica · 2023Article
- Progesterone from ovulatory menstrual cycles is an important cause of breast cancer.Breast cancer research : BCR · 2023Review
- Prevalence of Neoplasms among Former Adolescent Psychiatric Inpatients.Psychiatry investigation · 2019Article
- Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.GeroScience · 2019Review
- Sampling strategies for selecting general population comparison cohorts.Clinical epidemiology · 2018Article
- Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies.Systematic reviews · 2017Article
- Eating Disorders and Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Observational
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A diet with restricted energy content reduces the occurrence of cancer in animal experiments. It is not known if the underlying mechanism also exists in human beings. To determine whether cancer incidence is reduced among patients with anorexia nervosa who tend to have a low intake of energy, we carried out a retrospective cohort study of 22 654 women and 1678 men diagnosed with anorexia nervosa at ages 10-50 years during 1968-2010 according to National Hospital Registers in Sweden, Denmark and Finland. The comparison group consisted of randomly selected persons from population registers who were similar to the anorexia nervosa patients in respect to sex, year of birth and place of residence. Patients and population comparisons were followed for cancer by linkage to Cancer Registries. Incidence rate ratios (IRR) were estimated using Poisson models. In total, 366 cases of cancer (excluding non-melanoma skin cancer) were seen among women with anorexia nervosa, and the IRR for all cancer sites was 0.97 (95% CI = 0.87-1.08) adjusted for age, parity and age at first child. There were 76 breast cancers corresponding to an adjusted IRR of 0.61 (95% CI = 0.49-0.77). Significantly increased IRRs were observed for esophageal, lung, and liver cancer. Among men with anorexia nervosa, there were 23 cases of cancer (age-adjusted IRR = 1.08; 95% CI = 0.71-1.66). There seems to be no general reduction in cancer occurrence among patients with anorexia nervosa, giving little support to the energy restriction hypothesis.
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