ArticleScientific reports2015
Hearing the light: neural and perceptual encoding of optogenetic stimulation in the central auditory pathway.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Intensity modulation of frequency-specific optoacoustic stimulation at the peripheral hearing level.Zeitschrift fur medizinische Physik · 2026Article
- Differential optogenetic activation of the auditory midbrain in freely moving behaving mice.Frontiers in systems neuroscience · 2023Article
- Article
- Cochlear implants and other inner ear prostheses: today and tomorrow.Current opinion in physiology · 2020Article
- Dynamic Impairment of Olfactory Behavior and Signaling Mediated by an Olfactory Corticofugal System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Towards the optical cochlear implant: optogenetic approaches for hearing restoration.EMBO molecular medicine · 2020Review
- Article
- Optimizing optogenetic stimulation protocols in auditory corticofugal neurons based on closed-loop spike feedback.Journal of neural engineering · 2019Article
- Toward the Optical Cochlear Implant.Cold Spring Harbor perspectives in medicine · 2019Review
- First biocompatibility margins for optical stimulation at the eardrum via 532-nm laser pulses in a mouse model.Journal of biomedical optics · 2019Article
- Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation.Scientific reports · 2019Article
- Auditory Brainstem Implants: Recent Progress and Future Perspectives.Frontiers in neuroscience · 2019Review
- Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates.Frontiers in neuroscience · 2019Article
- Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos.The EMBO journal · 2018Article
- Optimized Chronos sets the clock for optogenetic hearing restoration.The EMBO journal · 2018Article
- Neural encoding of sensory and behavioral complexity in the auditory cortex.Current opinion in neurobiology · 2018Review
- Theoretical analysis of low-power fast optogenetic control of firing of Chronos-expressing neurons.Neurophotonics · 2018Article
- Progress and challenges for understanding the function of cortical microcircuits in auditory processing.Nature communications · 2017Review
- A Corticothalamic Circuit for Dynamic Switching between Feature Detection and Discrimination.Neuron · 2017Article
- High-fidelity optical excitation of cortico-cortical projections at physiological frequencies.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Optogenetics provides a means to dissect the organization and function of neural circuits. Optogenetics also offers the translational promise of restoring sensation, enabling movement or supplanting abnormal activity patterns in pathological brain circuits. However, the inherent sluggishness of evoked photocurrents in conventional channelrhodopsins has hampered the development of optoprostheses that adequately mimic the rate and timing of natural spike patterning. Here, we explore the feasibility and limitations of a central auditory optoprosthesis by photoactivating mouse auditory midbrain neurons that either express channelrhodopsin-2 (ChR2) or Chronos, a channelrhodopsin with ultra-fast channel kinetics. Chronos-mediated spike fidelity surpassed ChR2 and natural acoustic stimulation to support a superior code for the detection and discrimination of rapid pulse trains. Interestingly, this midbrain coding advantage did not translate to a perceptual advantage, as behavioral detection of midbrain activation was equivalent with both opsins. Auditory cortex recordings revealed that the precisely synchronized midbrain responses had been converted to a simplified rate code that was indistinguishable between opsins and less robust overall than acoustic stimulation. These findings demonstrate the temporal coding benefits that can be realized with next-generation channelrhodopsins, but also highlight the challenge of inducing variegated patterns of forebrain spiking activity that support adaptive perception and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.