ArticlePLoS genetics2015
Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- MiR-92 Controls Synaptic Development Through Glial Vha55 Regulation.Biomolecules · 2025Article
- Temporal miRNA Biomarkers for Pupal Age Estimation inInsects · 2025Article
- In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors.PLoS genetics · 2025Article
- Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions.Nature aging · 2025Article
- From the Making of a Neural Lineage to the Making of a Tumor: Lessons from the "Simple" Drosophila Brain.Advances in experimental medicine and biology · 2025Review
- Genetic regulation of microRNAs in the older adult brain and their contribution to neuropsychiatric conditions.bioRxiv : the preprint server for biology · 2024Article
- The Biological Roles of microRNAs inInsects · 2024Review
- Integrated analysis of miRNA profiles and gut bacterial changes inEcology and evolution · 2023Article
- Characterisation of the role and regulation ofFrontiers in cell and developmental biology · 2023Article
- Review
- MiR-92 Family Members Form a Cluster Required for Notochord Tubulogenesis in UrochordateGenes · 2021Article
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- MiR-92b-3p inhibits proliferation and migration of C2C12 cells.Cell cycle (Georgetown, Tex.) · 2020Article
- Molecular mechanisms regulating axon responsiveness at the midline.Developmental biology · 2020Article
- Article
- Small RNA Sequencing Reveals Regulatory Roles of MicroRNAs in the Development ofInternational journal of molecular sciences · 2019Article
- MicroRNA-92 Expression in CD133Cancer research · 2019Article
- Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression.Genes · 2019Review
- MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila.Cell reports · 2018Article
- Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution.PLoS genetics · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Intragenic microRNAs (miRNAs), located mostly in the introns of protein-coding genes, are often co-expressed with their host mRNAs. However, their functional interaction in development is largely unknown. Here we show that in Drosophila, miR-92a and miR-92b are embedded in the intron and 3'UTR of jigr1, respectively, and co-expressed with some jigr1 isoforms. miR-92a and miR-92b are highly expressed in neuroblasts of larval brain where Jigr1 expression is low. Genetic deletion of both miR-92a and miR-92b demonstrates an essential cell-autonomous role for these miRNAs in maintaining neuroblast self-renewal through inhibiting premature differentiation. We also show that miR-92a and miR-92b directly target jigr1 in vivo and that some phenotypes due to the absence of these miRNAs are partially rescued by reducing the level of jigr1. These results reveal a novel function of the miR-92 family in Drosophila neuroblasts and provide another example that local negative feedback regulation of host genes by intragenic miRNAs is essential for animal development.
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