Evidence map›Paper›PMID 26000339›Full record

ArticleJournal of nature and science2015

Subtype-dependent Morphological and Functional Degeneration of Retinal Ganglion Cells in Mouse Models of Experimental Glaucoma.

Zhen Puyang, Hui Chen, Xiaorong Liu

Abstract read
In one paragraph

Article in Journal of nature and science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  6. Review
  7. Article
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  9. Review
  10. Non-Cell Autonomous Roles for CASK in Optic Nerve Hypoplasia.Investigative ophthalmology & visual science · 2019
    Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhen PuyangDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA ; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Hui ChenDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Xiaorong LiuDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA ; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois 60208, USA.

Funding

Neurotrophic Mechanisms in Retinal Ganglion Cell MaturationR01EY019034 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG · 2008 to 2011
$1.4M
NEI NIH HHS R01 EY019034
6 · The paper itself

Abstract

In this short review, Puyang and her colleagues compared the results from three laboratories on the dendritic and functional degeneration of retinal ganglion cells (RGCs) in mouse models of experimental glaucoma [1-4]. Acute or chronic ocular hypertension was induced in mice, and different techniques were applied to identify RGC types. The dendritic alternations of RGCs were examined following the induction of ocular hypertension, and their light response properties were characterized by the multi-electrode array (MEA) recording. These studies support the notion that the morphological and functional degeneration of RGCs are subtype-dependent in experimental glaucoma.

Indexed as

Dendritic DegenerationExperimental GlaucomaMulti-Electrode Array (MEA)Retinal Ganglion Cells (RGCs)

Identifiers

PMID26000339
PMCPMC4437223

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.