ReviewBioMed research international2015
The pleiotropic effects of vitamin D in gynaecological and obstetric diseases: an overview on a hot topic.
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- A plethora of laboratory protocols for vitamin D receptor (VDR) gene variants detection: a systematic review of associations with hypertensive disorders of pregnancy.BMC pregnancy and childbirth · 2025Pooled it
- Association of vitamin D receptor genetic polymorphisms with the risk of infertility: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis.PloS one · 2023Pooled it
- Vitamin D and Ovarian Cancer: Systematic Review of the Literature with a Focus on Molecular Mechanisms.Cells · 2020Pooled it
- Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research.International journal of molecular sciences · 2018Pooled it
- Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial.Medical science monitor : international medical journal of experimental and clinical research · 2016Trial
- Review
- Vitamin D Knowledge, Attitudes, Practices and Serum Concentration Among Pregnant Women Attending a Malaysian Tertiary Hospital.Food science & nutrition · 2025Article
- Role of macronutrients, dairy products, fruits and vegetables in occurrence and progression of endometriosis: A summary of current evidence in a systematic review.Facts, views & vision in ObGyn · 2024Article
- Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis.Reproductive health · 2024Review
- The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review.Nutrients · 2023Review
- Maternal vitamin D deficiency in early pregnancy and perinatal and long-term outcomes.Heliyon · 2023Article
- The Effects of Vitamin D Supplementation before 20 Weeks of Gestation on Preeclampsia: A Systematic Review.Journal of personalized medicine · 2023Review
- Effect of Vitamin D analog supplementation on levator ani strength and plasma Vitamin D receptor expression in uterine prolapse patients.Scientific reports · 2023Article
- Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome.Irish journal of medical science · 2022Article
- Changes in MCP-1, HGF, and IGF-1 expression in endometrial stromal cells, PBMCs, and PFMCs of endometriotic women following 1,25(OH)2D3 treatment.Journal of cellular and molecular medicine · 2022Article
- Epigenomic and enhancer dysregulation in uterine leiomyomas.Human reproduction update · 2022Review
- Impact of lifestyle and diet on endometriosis: a fresh look to a busy corner.Przeglad menopauzalny = Menopause review · 2022Review
- Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women.BMC pregnancy and childbirth · 2022Article
- VDR Gene Polymorphisms and Cluster Headache Susceptibility: Case-Control Study in a Southeastern European Caucasian Population.Journal of molecular neuroscience : MN · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The traditionally recognized role of vitamin D consists in the regulation of bone metabolism and calcium-phosphorus homeostasis but recently a lot of in vitro and in vivo studies recognized several "noncalcemic" effects of vitamin D metabolites. Accumulating evidence suggests that the metabolic pathways of this vitamin may play a key role in the developing of gynaecological/obstetric diseases. VDR-mediated signalling pathways and vitamin D levels seem to (deeply) affect the risk of several gynaecological diseases, such as polycystic ovary syndrome (PCOS), endometriosis, and ovarian and even breast cancer. On the other hand, since also the maternal-fetal unit is under the influence of vitamin D, a breakdown in its homeostasis may underlie infertility, preeclampsia, and gestational diabetes mellitus (GDM). According to our literature review, the relationship between vitamin D and gynaecological/obstetric diseases must be replicated in future studies which could clarify the molecular machineries behind their development. We suggest that further investigation should take into account the different serum levels of this vitamin, the several actions which arise from the binding between it and its receptor (taking into account its possible polymorphism), and finally the interplay between vitamin D metabolism and other hormonal and metabolic pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.