ReviewBioMed research international2015
Vitamin D and inflammatory bowel disease.
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Diet and inflammatory bowel disease: The Asian Working Group guidelines.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Guideline
- Trial
- Trial
- May nutrients and dietary supplements influence the gut-lung microbiota axis in chronic obstructive pulmonary disease and exacerbations?Archives of medical science : AMS · 2026Article
- The Role of Vitamin D in Inflammatory Bowel Diseases: From Deficiency to Targeted Therapeutics and Precise Nutrition Strategies.Nutrients · 2025Review
- Association between vitamin C, D, and K intake and inflammatory bowel disease risk: findings from 2009 to 2010 NHANES.BMC gastroenterology · 2025Article
- Multiple electrolytes imbalances in a patient with inflammatory bowel disease associated with vitamin D deficiency: a case report.Journal of medical case reports · 2024Article
- Maximizing Treatment Options for IBD through Drug Repurposing.Current pharmaceutical design · 2024Review
- Vitamin D3 induces stem cell activation via Lgr5-Bmi1 expression and improving mouse colitis histology index.Narra J · 2023Article
- Assessing vitamin D as a biomarker in inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Article
- Adenovirus is prevalent in juvenile polyps and correlates with low vitamin D receptor expression.Pediatric research · 2022Article
- Vitamin D supplementation for autoimmune hepatitis: A need for further investigation.World journal of hepatology · 2022Article
- Vitamin DFrontiers in immunology · 2022Article
- Novel microbiota-related gene set enrichment analysis identified osteoporosis associated gut microbiota from autoimmune diseases.Journal of bone and mineral metabolism · 2021Article
- Role of vitamin D in Wnt pathway activation for colonic epithelial cell differentiation.Journal of Taibah University Medical Sciences · 2021Article
- Is there a relation between vitamin D, interleukin-17, and bone mineral density in patients with inflammatory bowel disease?Archives of medical science : AMS · 2021Article
- Vitamin D and the Host-Gut Microbiome: A Brief Overview.Acta histochemica et cytochemica · 2020Review
- Measuring Vitamin D Status in Chronic Inflammatory Disorders: How does Chronic Inflammation Affect the Reliability of Vitamin D Metabolites in Patients with IBD?Journal of clinical medicine · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency has been recognized as an environmental risk factor for Crohn's disease since the early 80s. Initially, this finding was correlated with metabolic bone disease. Low serum 25-hydroxyvitamin D levels have been repeatedly reported in inflammatory bowel diseases together with a relationship between vitamin D status and disease activity. Subsequently, low serum vitamin D levels have been reported in various immune-related diseases pointing to an immunoregulatory role. Indeed, vitamin D and its receptor (VDR) are known to interact with different players of the immune homeostasis by controlling cell proliferation, antigen receptor signalling, and intestinal barrier function. Moreover, 1,25-dihydroxyvitamin D is implicated in NOD2-mediated expression of defensin-β2, the latter known to play a crucial role in the pathogenesis of Crohn's disease (IBD1 gene), and several genetic variants of the vitamin D receptor have been identified as Crohn's disease candidate susceptibility genes. From animal models we have learned that deletion of the VDR gene was associated with a more severe disease. There is a growing body of evidence concerning the therapeutic role of vitamin D/synthetic vitamin D receptor agonists in clinical and experimental models of inflammatory bowel disease far beyond the role of calcium homeostasis and bone metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.