ArticleFrontiers in pediatrics2015
Evaluation of Gestational Diabetes Mellitus Risk in South Indian Women Based on MTHFR (C677T) and FVL (G1691A) Mutations.
Article in Frontiers in pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Associations of MTHFR Polymorphisms and Cytosine Modifications with Early-Gestational Diabetes Mellitus in Chinese Pregnant Women.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Associations of Maternal rs1801131 Genotype inNutrients · 2022Article
- Association of MTHFR gene polymorphism C677T (rs1801133) studies with early primary knee osteoarthritis in a South Indian population: a hospital-based study.African health sciences · 2022Article
- The prevalence of Factor V Leiden (Arg506Gln) mutation in King Khalid University Hospital patients, 2017-2019.Nagoya journal of medical science · 2021Article
- Peripheral Vascular Disease Susceptibility Based on Diabetes Mellitus and rs17367504 Polymorphism of the MTHFR Gene.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- No Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy andDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- The CDKN2A polymorphisms and the susceptibility of HBV-related gestational diabetes mellitus.Journal of clinical laboratory analysis · 2018Article
- Exploration of CAG triplet repeat in nontranslated region of SCA12 gene.Journal of genetics · 2016Article
- Importance of glucokinase -258G/A polymorphism in Asian Indians with post-transplant and type 2 diabetes mellitus.Intractable & rare diseases research · 2016Article
- Association of GSTs polymorphisms with risk of gestational diabetes mellitus.International journal of clinical and experimental pathology · 2015Article
- Genetics of Gestational Diabetes Mellitus - The Indian Perspective.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to scrutinize the extent to which single amino acid substitutions in the MTHFR and factor V Leiden (FVL) genes affect the risk of gestational diabetes mellitus (GDM) in pregnant women of South Indian descendant. This case-control study was implemented once the ethical approval has been obtained. Overall, 237 women were recruited in this study: 137 had been diagnosed with GDM and the remaining 100 women were used as normal controls or non-GDM. The diagnosis of GDM was confirmed with biochemical analysis, i.e., GCT and oral glucose tolerance tests. Five milliliters of peripheral blood was collected and used for biochemical and molecular analyses. DNA was isolated, and genotyping for MTHFR (C677T) and FVL (G1691A) mutations was performed using PCR-RFLP. FVL (G1691A) locus was not polymorphic in the investigated sample. There was no significant difference in the allele and genotype frequencies of C677T polymorphism between GDM and non-GDM women (p = 0.8892).
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