Evidence map›Paper›PMID 26000154›Full record

ReviewAuto- immunity highlights2014

Pathogenesis and potential therapeutic targets in systemic lupus erythematosus: from bench to bedside.

D Squatrito, G Emmi, E Silvestri, L Ciucciarelli, M M D'Elios, D Prisco, L Emmi

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Auto- immunity highlights, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
  7. Article
  8. Association of long non-coding RNA GAS5 and miR-21 levels in CD4Experimental and therapeutic medicine · 2018
    Article
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  10. Review
  11. Review
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  14. Article
  15. Review
  16. Peripheral Ulcerative Keratitis: A Review.Journal of ophthalmic & vision research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

D SquatritoSOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
G EmmiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
E SilvestriSOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
L CiucciarelliSOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
M M D'EliosSOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
D PriscoSOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
L EmmiSOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy.
Azienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is considered an autoimmune disease with multiorgan involvement. Many advances have been made during the last decade regarding inflammatory pathways, genetic and epigenetic alterations, adaptive and innate immune system mechanisms specifically involved in SLE pathogenesis. Apoptosis has been proposed as an important player in SLE pathogenesis more than a decade ago. However, only recently new key apoptotic pathways have been investigated and the link between apoptotic debris containing autoantigens, innate immunity and ongoing inflammation has been further elucidated. Better understanding of cellular mechanisms and involved cytokines contributed to the development of new biological drugs specifically addressed for SLE therapy.

Indexed as

Apoptosis in SLEAutoantibodiesAutoimmune diseasesBiologic therapiesSystemic lupus erythematosus

Identifiers

PMID26000154
PMCPMC4389042
OpenAlexW2053886751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.