Evidence map›Paper›PMID 26000145›Full record

ArticleAuto- immunity highlights2013

Natural killer cells in patients with severe chronic fatigue syndrome.

E W Brenu, S L Hardcastle, G M Atkinson, M L van Driel, S Kreijkamp-Kaspers, K J Ashton, D R Staines, S M Marshall-Gradisnik

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Auto- immunity highlights, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

E W BrenuGriffith Health Institute, School of Medical Science, Griffith University, Gold Coast, QLD Australia ; The National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD Australia ; Immunology Research Group, Centre for Medicine and Oral Health, Griffith University, GH1, Room 7.59, Southport, QLD 4215 Australia.
S L HardcastleGriffith Health Institute, School of Medical Science, Griffith University, Gold Coast, QLD Australia ; The National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD Australia.
G M AtkinsonGriffith Health Institute, School of Medical Science, Griffith University, Gold Coast, QLD Australia ; The National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD Australia.
M L van DrielQueensland Health, Gold Coast Public Health Unit, Robina, Gold Coast, QLD Australia.
S Kreijkamp-KaspersFaculty of Health Sciences and Medicine, Bond University, Robina, QLD Australia.
K J AshtonFaculty of Health Sciences and Medicine, Bond University, Robina, QLD Australia.
D R StainesThe National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD Australia ; Queensland Health, Gold Coast Public Health Unit, Robina, Gold Coast, QLD Australia.
S M Marshall-GradisnikGriffith Health Institute, School of Medical Science, Griffith University, Gold Coast, QLD Australia ; The National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD Australia.
Bond University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms.

Indexed as

Chronic fatigue syndromeCytotoxicityGranzymesNatural killer cellsPerforin

Identifiers

PMID26000145
PMCPMC4389023
OpenAlexW2046048283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.