ArticleInterventional neurology2015
Large deep white matter lesions may predict futile recanalization in endovascular therapy for acute ischemic stroke.
Article in Interventional neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Effects of hypertension in patients receiving mechanical thrombectomy: A meta-analysis.Medicine · 2020Pooled it
- Mapping DWI signal reversal and long-term tissue outcomes following endovascular therapy in acute ischemic stroke.European radiology · 2026Article
- No-reflow after recanalization in ischemic stroke: From pathomechanisms to therapeutic strategies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Comprehensive Meta-Analysis of Futile Recanalization in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: Prevalence, Factors, and Clinical Outcomes.Life (Basel, Switzerland) · 2023Review
- Nomogram-Based Prediction of the Futile Recanalization Risk Among Acute Ischemic Stroke Patients Before and After Endovascular Therapy: A Retrospective Study.Neuropsychiatric disease and treatment · 2023Article
- Lymphocyte to Monocyte Ratio is Independently Associated with Futile Recanalization in Acute Ischemic Stroke After Endovascular Therapy.Neuropsychiatric disease and treatment · 2023Article
- Predictors of futile recanalization in patients with acute ischemic stroke undergoing mechanical thrombectomy in late time windows.Frontiers in neurology · 2022Article
- Multiple-Factor Analyses of Futile Recanalization in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy.Frontiers in neurology · 2021Article
- Futile Recanalization after Endovascular Therapy in Acute Ischemic Stroke.BioMed research international · 2018Review
- Cerebral regions preserved by successful endovascular recanalization of acute M1 segment occlusions: a voxel based analysis.The British journal of radiology · 2017Article
- DWI Lesion Patterns Predict Outcome in Stroke Patients with Thrombolysis.Cerebrovascular diseases (Basel, Switzerland) · 2015Article
- Cerebral venous collaterals: A new fort for fighting ischemic stroke?Progress in neurobiologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study investigated whether large ischemic lesions in the deep white matter (DWM) on pretreatment diffusion-weighted MRI (DWI) predict futile recanalization.
methodsConsecutive acute stroke patients with anterior circulation ischemia who underwent successful arterial recanalization with thrombolysis in cerebral infarction grade 2b or 3 were enrolled. A large DWI-DWM lesion was defined as a hyperintense lesion in the DWM on initial DWI, located mainly between the anterior and posterior horns of the lateral ventricle. The Alberta Stroke Program Early CT score on CT and DWI and stroke volume on initial DWI were recorded. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) score. Futile recanalization was defined as a 30-day modified Rankin scale score of 3-6 despite successful recanalization. Univariate and multivariate regression analyses were performed to identify predictors of futile recanalization.
resultsIn 35 of 46 patients (76%) with successful recanalization, futile recanalization was observed in 20 patients (57%). Patients with futile recanalization were older (median age 74 vs. 58 years; p = 0.053), had higher initial NIHSS scores (median 17 vs. 9; p = 0.042), and a higher prevalence of large DWI-DWM lesions (45 vs. 9%; p = 0.022). Logistic regression analysis showed that a large DWI-DWM lesion was an independent predictor of futile recanalization (OR 13.97; 95% CI 1.32-147.73; p = 0.028).
conclusionPatients with large preintervention DWI-DWM lesions may be poor candidates for endovascular therapy.
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