ArticleFrontiers in plant science2015
LSD1 and HY5 antagonistically regulate red light induced-programmed cell death in Arabidopsis.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 80 citations in OpenAlex.
- Rice LSD1-like Genes: Genome-Wide Characterization and Evidence Linking OsLSD3 to Plant Height.Plants (Basel, Switzerland) · 2026Article
- Red Light Triggers Lesion Formation in thePlants (Basel, Switzerland) · 2026Article
- Light-Signalling Regulators GmSTF3/4 Enhance Soybean Susceptibility to Cyst Nematodes via Activation of Sugar Transporters.Plant biotechnology journal · 2025Article
- Redox regulation of LSD1/CATALASE 2 phase separation condensates controls location and functions.The New phytologist · 2025Article
- Light Quality Plays a Crucial Role in Regulating Germination, Photosynthetic Efficiency, Plant Development, Reactive Oxygen Species Production, Antioxidant Enzyme Activity, and Nutrient Acquisition in Alfalfa.International journal of molecular sciences · 2025Article
- Light signaling regulates root-knot nematode infection and development via HY5-SWEET signaling.BMC plant biology · 2024Article
- The cotton MYB33 gene is a hub gene regulating the trade-off between plant growth and defense in Verticillium dahliae infection.Journal of advanced research · 2024Article
- METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress.International journal of molecular sciences · 2024Article
- Full-length RNA sequencing and single-nucleus sequencing deciphers programmed cell death and developmental trajectories in laticiferous canals ofFrontiers in plant science · 2024Article
- Red light induces salicylic acid accumulation by activating CaHY5 to enhance pepper resistance againstHorticulture research · 2023Article
- Novel Mechanisms Underlying Rubber Accumulation and Programmed Cell Death in Laticiferous Canals ofPlants (Basel, Switzerland) · 2023Article
- Salicylic acid metabolism and signalling coordinate senescence initiation in aspen in nature.Nature communications · 2023Article
- Light-Dependent Regulatory Interactions between the Redox System and miRNAs and Their Biochemical and Physiological Effects in Plants.International journal of molecular sciences · 2023Review
- Tuning the Wavelength: Manipulation of Light Signaling to Control Plant Defense.International journal of molecular sciences · 2023Review
- Exploring the metabolic and physiological roles ofFrontiers in plant science · 2023Article
- Mutation ofInternational journal of molecular sciences · 2022Article
- Light Intensity- and Spectrum-Dependent Redox Regulation of Plant Metabolism.Antioxidants (Basel, Switzerland) · 2022Review
- APIP5 functions as a transcription factor and an RNA-binding protein to modulate cell death and immunity in rice.Nucleic acids research · 2022Article
- Abscisic acid-induced cytoplasmic translocation of constitutive photomorphogenic 1 enhances reactive oxygen species accumulation through the HY5-ABI5 pathway to modulate seed germination.Plant, cell & environment · 2022Article
- Antagonistic modules regulate photosynthesis-associated nuclear genes via GOLDEN2-LIKE transcription factors.Plant physiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death (PCD) in plant is triggered by abiotic and biotic stress. Light-dependent PCD is unique to plants. Light-induced PCD also requires reactive oxygen species (ROS) and salicylic acid (SA). In this study, lesion simulating disease1 (LSD1) and elongated hypocotyl 5 (HY5) perform opposite roles to regulate excess red light (RL)-triggered PCD associated with ROS and SA production. Under RL, the lsd1 mutant released more ROS and SA and displayed a stronger cell death rate than the hy5 mutant. It was shown that active LSD1 converted into inactive form by changing the redox status of the plastoquinone pool, and HY5 interacted with phytochrome B (phyB) to promote PCD in response to RL. LSD1 inhibited the enhanced disease susceptibility 1 (EDS1) expression by upregulating SR1, whereas HY5 enhanced the enhanced EDS1 expression by binding to the G-box of the EDS1 promoter. This study suggested that LSD1 and HY5 antagonistically modulated EDS1-dependent ROS and SA signaling; thus, PCD was mediated in response to RL.
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