Evidence map›Paper›PMID 25999865›Full record

ArticleFrontiers in psychiatry2015

A parietal biomarker for ADHD liability: as predicted by the distributed effects perspective model of ADHD.

T Sigi Hale, Joshua F Wiley, Susan L Smalley, Kelly L Tung, Olivia Kaminsky, James J McGough, Ashwin M Jaini, Sandra K Loo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Inter-hemispheric Asymmetry Patterns in the ADHD Brain: A Neuroimaging Replication Study.Proceedings of SPIE--the International Society for Optical Engineering · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T Sigi HaleDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Semel Institute for Neuroscience and Human Behavior , Los Angeles, CA , USA.
Joshua F WileyDepartment of Psychology, University of California Los Angeles , Los Angeles, CA , USA.
Susan L SmalleyDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Semel Institute for Neuroscience and Human Behavior , Los Angeles, CA , USA.
Kelly L TungDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Semel Institute for Neuroscience and Human Behavior , Los Angeles, CA , USA.
Olivia KaminskyDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Semel Institute for Neuroscience and Human Behavior , Los Angeles, CA , USA.
James J McGoughDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Semel Institute for Neuroscience and Human Behavior , Los Angeles, CA , USA.
Ashwin M JainiDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Semel Institute for Neuroscience and Human Behavior , Los Angeles, CA , USA.
Sandra K LooDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Semel Institute for Neuroscience and Human Behavior , Los Angeles, CA , USA.

Funding

DETECTION OF SUSCEPTIBILITY GENES IN ADHDR01MH058277 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALLEY, SUSAN L · 1998 to 2008
$4.6M
Genetics of EEG Patterns in ADHDR01NS054124 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, SANDRA K · 2006 to 2010
$1.7M
Neurobiology of Atypical Cerebral Asymmetry in ADHDR00MH082104 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HALE, TODD SIGI · 2010 to 2012
$736k
Genetic Underpinnings of EEG Patterns in ADHDK23HD040275 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, SANDRA K · 2002 to 2006
$628k
Neurobiology of Atypical Cerebral Asymmetry in ADHDK99MH082104 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HALE, TODD SIGI · 2008 to 2009
$180k
NICHD NIH HHS K23 HD040275NIMH NIH HHS K99 MH082104NIMH NIH HHS R00 MH082104NIMH NIH HHS R01 MH058277NINDS NIH HHS R01 NS054124
6 · The paper itself

Abstract

backgroundWe previously hypothesized that poor task-directed sensory information processing should be indexed by increased weighting of right hemisphere (RH) biased attention and visuo-perceptual brain functions during task operations and have demonstrated this phenotype in ADHD across multiple studies, using multiple methodologies. However, in our recent distributed effects model of ADHD, we surmised that this phenotype is not ADHD specific, but rather more broadly reflective of any circumstance that disrupts the induction and maintenance of an emergent task-directed neural architecture. Under this view, increased weighting of RH-biased attention and visuo-perceptual brain functions is expected to generally index neurocognitive sets that are not optimized for task-directed thought and action, and when durable expressed, liability for ADHD.

methodThe current study tested this view by examining whether previously identified rightward parietal EEG asymmetry in ADHD was associated with common ADHD characteristics and comorbidities [i.e., ADHD risk factors (RFs)].

resultsBarring one exception (non-right handedness), we found that it was. Rightward parietal asymmetry (RPA) was associated with carrying the DRD4-7R risk allele, being male, having mood disorder, and having anxiety disorder. However, differences in the specific expression of RPA were observed, which are discussed in relation to possible unique mechanisms underlying ADHD liability in different ADHD RFs.

conclusionRightward parietal asymmetry appears to be a durable feature of ADHD liability, as predicted by the Distributed Effects Perspective Model of ADHD. Moreover, variability in the expression of this phenotype may shed light on different sources of ADHD liability.

Indexed as

ADHDasymmetryattentionDRD4lateralityliabilityparietalrisk factors

Identifiers

PMID25999865
PMCPMC4423436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.