ArticleFrontiers in neuroscience2015
Sub-millimeter T2 weighted fMRI at 7 T: comparison of 3D-GRASE and 2D SE-EPI.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Cerebellar imaging for neuroscience at 9.4 T.Magnetic resonance in medicine · 2025Article
- Higher spatial resolution and sensitivity in whole brain functional MRI at 7T using 3D EPI accelerated with variable density CAIPI sampling and temporal random walk.Magnetic resonance in medicine · 2025Article
- Layer-specific BOLD effects in gradient and spin-echo acquisitions in somatosensory cortex.Magnetic resonance in medicine · 2025Article
- Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7T: Challenges and capabilities.PloS one · 2023Article
- Simultaneous pure TNeuroImage · 2021Article
- Article
- Using high spatial resolution fMRI to understand representation in the auditory network.Progress in neurobiology · 2021Review
- Layer-dependent functional connectivity methods.Progress in neurobiology · 2021Review
- New acquisition techniques and their prospects for the achievable resolution of fMRI.Progress in neurobiology · 2021Review
- Ultra-High-Field Neuroimaging Reveals Fine-Scale Processing for 3D Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Highly accelerated submillimeter resolution 3D GRASE with controlledMagnetic resonance in medicine · 2021Article
- An in-vivo study of BOLD laminar responses as a function of echo time and static magnetic field strength.Scientific reports · 2021Article
- Forging a path to mesoscopic imaging success with ultra-high field functional magnetic resonance imaging.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Validating Linear Systems Analysis for Laminar fMRI: Temporal Additivity for Stimulus Duration Manipulations.Brain topography · 2021Article
- Correcting for Superficial Bias in 7T Gradient Echo fMRI.Frontiers in neuroscience · 2021Article
- Comparison of BOLD and CBV using 3D EPI and 3D GRASE for cortical layer functional MRI at 7 T.Magnetic resonance in medicine · 2020Article
- Article
- Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations.Scientific reports · 2020Article
- Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRNeuroImage · 2019Review
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7 authors.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) allows studying human brain function non-invasively up to the spatial resolution of cortical columns and layers. Most fMRI acquisitions rely on the blood oxygenation level dependent (BOLD) contrast employing T(*) 2 weighted 2D multi-slice echo-planar imaging (EPI). At ultra-high magnetic field (i.e., 7 T and above), it has been shown experimentally and by simulation, that T2 weighted acquisitions yield a signal that is spatially more specific to the site of neuronal activity at the cost of functional sensitivity. This study compared two T2 weighted imaging sequences, inner-volume 3D Gradient-and-Spin-Echo (3D-GRASE) and 2D Spin-Echo EPI (SE-EPI), with evaluation of their imaging point-spread function (PSF), functional specificity, and functional sensitivity at sub-millimeter resolution. Simulations and measurements of the imaging PSF revealed that the strongest anisotropic blurring in 3D-GRASE (along the second phase-encoding direction) was about 60% higher than the strongest anisotropic blurring in 2D SE-EPI (along the phase-encoding direction). In a visual paradigm, the BOLD sensitivity of 3D-GRASE was found to be superior due to its higher temporal signal-to-noise ratio (tSNR). High resolution cortical depth profiles suggested that the contrast mechanisms are similar between the two sequences, however, 2D SE-EPI had a higher surface bias owing to the higher T(*) 2 contribution of the longer in-plane EPI echo-train for full field of view compared to the reduced field of view of zoomed 3D-GRASE.
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